Carbon monoxide and anesthesia-induced neurotoxicity

The majority of commonly used anesthetic agents induce widespread neuronal degeneration in the developing mammalian brain. Downstream, the process appears to involve activation of the oxidative stress-associated mitochondrial apoptosis pathway. Targeting this pathway could result in prevention of an...

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Veröffentlicht in:	Neurotoxicology and teratology 2017-03, Vol.60, p.50-58
1. Verfasser:	Levy, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia-induced neurotoxicity Animals Apoptosis Apoptosis - drug effects Brain - drug effects Brain - growth & development Carbon monoxide Carbon Monoxide - pharmacology Cytoprotection Dose-Response Relationship, Drug Endogenous Exogenous Exposure General anesthesia Humans Isoflurane - adverse effects Low-flow anesthesia Mitochondria Mitochondria - drug effects Neurotoxicity Syndromes - prevention & control Oxidative stress Oxidative Stress - drug effects Prosencephalon - metabolism Prosencephalon - pathology Therapy
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