Innate Lymphoid Cells in Tumor Immunity

Innate Lymphoid Cells in Tumor Immunity

Innate lymphoid cells (ILCs) are a group of immune cells of the lymphoid lineage that do not possess antigen specificity. The group includes natural killer (NK) cells, lymphoid tissue inducer (LTi) cells and the recently identified ILC1s, ILC2s and ILC3s. Although the role of NK cells in the context...

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Veröffentlicht in:Biomedicines 2016-02, Vol.4 (1), p.7
Hauptverfasser: van Beek, Jasper J P, Martens, Anne W J, Bakdash, Ghaith, de Vries, I Jolanda M
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creator van Beek, Jasper J P
Martens, Anne W J
Bakdash, Ghaith
de Vries, I Jolanda M
description Innate lymphoid cells (ILCs) are a group of immune cells of the lymphoid lineage that do not possess antigen specificity. The group includes natural killer (NK) cells, lymphoid tissue inducer (LTi) cells and the recently identified ILC1s, ILC2s and ILC3s. Although the role of NK cells in the context of cancer has been well established, the involvement of other ILC subsets in cancer progression and resistance is just emerging. Here, we review the literature on the role of the different ILC subsets in tumor immunity and discuss its implications for cancer treatment and monitoring.
doi_str_mv 10.3390/biomedicines4010007
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title Innate Lymphoid Cells in Tumor Immunity
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