Role of Aquaporin 1 Signalling in Cancer Development and Progression
Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targe...
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| Veröffentlicht in: | International journal of molecular sciences 2017-02, Vol.18 (2), p.299-299 |
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| creator | Tomita, Yoko Dorward, Hilary Yool, Andrea J Smith, Eric Townsend, Amanda R Price, Timothy J Hardingham, Jennifer E |
| description | Cancer is a major health burden worldwide. Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways. |
| doi_str_mv | 10.3390/ijms18020299 |
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Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. 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Despite the advances in our understanding of its pathogenesis and continued improvement in cancer management and outcomes, there remains a strong clinical demand for more accurate and reliable biomarkers of metastatic progression and novel therapeutic targets to abrogate angiogenesis and tumour progression. Aquaporin 1 (AQP1) is a small hydrophobic integral transmembrane protein with a predominant role in trans-cellular water transport. Recently, over-expression of AQP1 has been associated with many types of cancer as a distinctive clinical prognostic factor. This has prompted researchers to evaluate the link between AQP1 and cancer biological functions. Available literature implicates the role of AQP1 in tumour cell migration, invasion and angiogenesis. 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Dorward, Hilary ; Yool, Andrea J ; Smith, Eric ; Townsend, Amanda R ; Price, Timothy J ; Hardingham, Jennifer E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-981c80bc18857457d445cadda7797c7e5fe4452b9aba1961815a8145e59292913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Aquaporin 1 - chemistry</topic><topic>Aquaporin 1 - genetics</topic><topic>Aquaporin 1 - metabolism</topic><topic>Aquaporins</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carrier Proteins</topic><topic>Cell adhesion & migration</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Disease Progression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes</topic><topic>Glycolysis</topic><topic>Humans</topic><topic>Hypoxia - genetics</topic><topic>Hypoxia - metabolism</topic><topic>Models, Biological</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Protein Binding</topic><topic>Review</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Yoko</creatorcontrib><creatorcontrib>Dorward, Hilary</creatorcontrib><creatorcontrib>Yool, Andrea J</creatorcontrib><creatorcontrib>Smith, Eric</creatorcontrib><creatorcontrib>Townsend, Amanda R</creatorcontrib><creatorcontrib>Price, Timothy J</creatorcontrib><creatorcontrib>Hardingham, Jennifer E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Yoko</au><au>Dorward, Hilary</au><au>Yool, Andrea J</au><au>Smith, Eric</au><au>Townsend, Amanda R</au><au>Price, Timothy J</au><au>Hardingham, Jennifer E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Aquaporin 1 Signalling in Cancer Development and Progression</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>18</volume><issue>2</issue><spage>299</spage><epage>299</epage><pages>299-299</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Cancer is a major health burden worldwide. 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| subjects | Angiogenesis Animals Aquaporin 1 - chemistry Aquaporin 1 - genetics Aquaporin 1 - metabolism Aquaporins Biomarkers Cancer Carrier Proteins Cell adhesion & migration Cell Movement - genetics Cell Proliferation Disease Progression Gene Expression Regulation, Neoplastic Genes Glycolysis Humans Hypoxia - genetics Hypoxia - metabolism Models, Biological Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Protein Binding Review Signal Transduction |
| title | Role of Aquaporin 1 Signalling in Cancer Development and Progression |
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