A real‐time digital bio‐imaging system to quantify cellular cytotoxicity as an alternative to the standard chromium‐51 release assay

Summary Reliable measurement of cellular cytotoxicity is essential for the characterization of immune responses and for the monitoring of antibody treatment efficacy. Until now, the standard 51Cr‐release assay has remained the sole sensitive assay that measures cellular cytotoxicity. Alternative non...

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Veröffentlicht in:	Immunology 2017-04, Vol.150 (4), p.489-494
Hauptverfasser:	Fassy, Julien, Tsalkitzi, Kyriaki, Salavagione, Emie, Hamouda‐Tekaya, Nedra, Braud, Véronique M.
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody‐dependent cell‐mediated cytotoxicity cell cytotoxic assay Cell Separation Cells, Cultured Chromium Radioisotopes cytotoxic T cells Cytotoxicity Cytotoxicity Tests, Immunologic - methods Cytotoxicity, Immunologic Flow Cytometry Fluorescent Dyes Humans Killer Cells, Natural - immunology lectin‐like transcript 1 Life Sciences natural killer cells Original Reproducibility of Results Sensitivity and Specificity T-Lymphocytes, Cytotoxic - immunology
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