PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells

Cancer cells are thought to use actin rich invadopodia to facilitate matrix degradation. Formation and maturation of invadopodia requires the co-ordained activity of Rho-GTPases, however the molecular mechanisms that underlie the invadopodia lifecycle are not fully elucidated. Previous work has sugg...

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Veröffentlicht in:	Oncotarget 2016-10, Vol.7 (43), p.70881-70897
Hauptverfasser:	Nicholas, Nicole S, Pipili, Aikaterini, Lesjak, Michaela S, Ameer-Beg, Simon M, Geh, Jenny L C, Healy, Ciaran, MacKenzie Ross, Alistair D, Parsons, Maddy, Nestle, Frank O, Lacy, Katie E, Wells, Claire M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Animals Cell Line, Tumor Fluorescent Antibody Technique HEK293 Cells Humans Melanoma - pathology Neoplasm Invasiveness - pathology p21-Activated Kinases - genetics p21-Activated Kinases - metabolism Podosomes - pathology Protein Isoforms - metabolism Research Paper Rho Guanine Nucleotide Exchange Factors - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction Skin Neoplasms - pathology Zebrafish
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