Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control

Advancements in adoptive cell transfer therapy (ACT) has led to the use of T cells engineered with tumor specific T cell receptors, which after rapid expansion can be obtained in sufficient numbers for treating patients. However, due to massive proliferation these cells are close to replicative sene...

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Veröffentlicht in:	Oncotarget 2016-10, Vol.7 (43), p.69371-69383
Hauptverfasser:	Kesarwani, Pravin, Chakraborty, Paramita, Gudi, Radhika, Chatterjee, Shilpak, Scurti, Gina, Toth, Kyle, Simms, Patt, Husain, Mahvash, Armeson, Kent, Husain, Shahid, Garrett-Mayer, Elizabeth, Vasu, Chethamarakshan, Nishimura, Michael I, Mehrotra, Shikhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - transplantation Cell Line, Tumor Humans Immunotherapy, Adoptive - methods Interferon-gamma - immunology Interferon-gamma - metabolism L-Selectin - immunology L-Selectin - metabolism Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - therapy Mice, Inbred C57BL Necrosis - immunology Receptor-Interacting Protein Serine-Threonine Kinases - immunology Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Research Paper: Immunology
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