Cytoplasmic vacuolization in cell death and survival
Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death;...
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| Veröffentlicht in: | Oncotarget 2016-08, Vol.7 (34), p.55863-55889 |
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| creator | Shubin, Andrey V Demidyuk, Ilya V Komissarov, Alexey A Rafieva, Lola M Kostrov, Sergey V |
| description | Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mechanisms of the vacuole formation and structure have become available. In addition, numerous examples of the association between vacuolization and previously unknown cell death types have been reported. Here, we review these data to make a deeper insight into the role of cytoplasmic vacuolization in cell death and survival. |
| doi_str_mv | 10.18632/oncotarget.10150 |
| format | Article |
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Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mechanisms of the vacuole formation and structure have become available. In addition, numerous examples of the association between vacuolization and previously unknown cell death types have been reported. 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| subjects | Animals Bacterial Infections - pathology Bacterial Proteins - physiology Cell Death Cell Survival Cytoplasm - ultrastructure Endoplasmic Reticulum - ultrastructure Endoplasmic Reticulum-Associated Degradation - physiology Humans Large-Conductance Calcium-Activated Potassium Channel alpha Subunits - physiology Necrosis Review Vacuoles - physiology Virus Diseases - pathology |
| title | Cytoplasmic vacuolization in cell death and survival |
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