Myeloid cell expressed proprotein convertase FURIN attenuates inflammation

The proprotein convertase enzyme FURIN processes immature pro-proteins into functional end- products. FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance. FURIN also promotes the infectivity of pathogens by activating bacteria...

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Veröffentlicht in:	Oncotarget 2016-08, Vol.7 (34), p.54392-54404
Hauptverfasser:	Cordova, Zuzet Martinez, Grönholm, Anna, Kytölä, Ville, Taverniti, Valentina, Hämäläinen, Sanna, Aittomäki, Saara, Niininen, Wilhelmiina, Junttila, Ilkka, Ylipää, Antti, Nykter, Matti, Pesu, Marko
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM17 Protein - metabolism Animals Caspase 1 - metabolism Furin - physiology Gene Expression Regulation Inflammation - prevention & control Interleukin-1beta - blood Lipopolysaccharides - toxicity Macrophages - metabolism Mice Mice, Inbred C57BL Myeloid Cells - enzymology Research Paper: Immunology Transforming Growth Factor beta1 - secretion
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