CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming

Increased expression of CD147 in pancreatic cancer has been proposed to play a critical role in cancer progression via CD147 chaperone function for lactate monocarboxylate transporters (MCTs). Here, we show for the first time that CD147 interacts with membrane transporters beyond MCTs and exhibits a...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (4), p.6742-6762
Hauptverfasser:	Kendrick, Agnieszka A, Schafer, Johnathon, Dzieciatkowska, Monika, Nemkov, Travis, D'Alessandro, Angelo, Neelakantan, Deepika, Ford, Heide L, Pearson, Chad G, Weekes, Colin D, Hansen, Kirk C, Eisenmesser, Elan Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Animals Basigin - genetics Basigin - metabolism Calcium Signaling Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Cellular Reprogramming Energy Metabolism Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice, Nude Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Plasma Membrane Calcium-Transporting ATPases - genetics Plasma Membrane Calcium-Transporting ATPases - metabolism Proteasome Endopeptidase Complex - metabolism Protein Binding Proteolysis Research Paper RNA Interference Time Factors Transfection Tumor Burden
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