NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma

Abstract Background Oxaliplatin-capecitabine (OxCap) and carboplatin-paclitaxel (CarPac) based neo-adjuvant chemoradiotherapy (nCRT) have shown promising activity in localised, resectable oesophageal cancer. Patients and methods A non-blinded, randomised (1:1 via a centralised computer system), ‘pic...

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Veröffentlicht in:	European journal of cancer (1990) 2017-03, Vol.74, p.38-46
Hauptverfasser:	Mukherjee, Somnath, Hurt, Christopher Nicholas, Gwynne, Sarah, Sebag-Montefiore, David, Radhakrishna, Ganesh, Gollins, Simon, Hawkins, Maria, Grabsch, Heike I, Jones, Gareth, Falk, Stephen, Sharma, Ricky, Bateman, Andrew, Roy, Rajarshi, Ray, Ruby, Canham, Jo, Griffiths, Gareth, Maughan, Tim, Crosby, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - therapy Administration, Oral Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Capecitabine - administration & dosage Capecitabine - adverse effects Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Chemoradiotherapy Chemoradiotherapy, Adjuvant - methods Chemotherapy Clinical trials Esophageal cancer Esophageal Neoplasms - therapy Esophagus Female Hematology, Oncology and Palliative Medicine Humans Infusions, Intravenous Male Middle Aged Morbidity Mortality Neo-adjuvant Neoadjuvant Therapy - methods Neutropenia Oesophageal Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Original Research Oxaliplatin Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects Patients Polymerase chain reaction Preoperative Care - methods Radiation therapy Radiotherapy Randomised phase II Randomization Surgery Toxicity Treatment Outcome
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