Protease‐activated receptor 4: from structure to function and back again

Protease‐activated receptors are a family of four GPCRs (PAR1–PAR4) with a number of unique attributes. Nearly two and a half decades after the discovery of the first PAR, an antagonist targeting this receptor has been approved for human use. The first‐in‐class PAR1 antagonist, vorapaxar, was approv...

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Veröffentlicht in:	British journal of pharmacology 2016-10, Vol.173 (20), p.2952-2965
Hauptverfasser:	French, Shauna L, Hamilton, Justin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals G protein-coupled receptors Humans Myocardial infarction Pharmacology Protease Receptor mechanisms Receptors, Thrombin - antagonists & inhibitors Receptors, Thrombin - chemistry Receptors, Thrombin - metabolism Review Structure-function relationships Themed Section: Review
Online-Zugang:	Volltext
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