Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a c...

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Veröffentlicht in:	Molecular cancer 2017-03, Vol.16 (1), p.57-57, Article 57
Hauptverfasser:	Ibrahim, Sherif Abdelaziz, Gadalla, Ramy, El-Ghonaimy, Eslam A, Samir, Omnia, Mohamed, Hossam Taha, Hassan, Hebatallah, Greve, Burkhard, El-Shinawi, Mohamed, Mohamed, Mona Mostafa, Götte, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Biomarkers Breast cancer Cell adhesion & migration Cell Line, Tumor Chemotherapy Cloning Cytokines Epidermal growth factor Female Gene Expression Gene Knockdown Techniques Gene Silencing Genotype & phenotype Humans Hyaluronan Receptors - metabolism Immunoglobulins Immunology Inflammation Inflammatory Breast Neoplasms - genetics Inflammatory Breast Neoplasms - metabolism Inflammatory Breast Neoplasms - pathology Interleukin-6 - metabolism Lymphocytes T Medical prognosis Metastasis Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology NF-kappa B - metabolism NF-κB protein Notch1 protein Phenotype Proteome Proteomics - methods Receptor, Epidermal Growth Factor - metabolism Receptors, Notch - metabolism Signal Transduction STAT3 Transcription Factor - metabolism Stem cells Syndecan-1 - genetics Syndecan-1 - metabolism Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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