Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families

Metagenomics has made accessible an enormous reserve of global biochemical diversity. To tap into this vast resource of novel enzymes, we have screened over one million clones from metagenome DNA libraries derived from sixteen different environments for carboxylesterase activity and identified 714 p...

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Veröffentlicht in:	Scientific reports 2017-03, Vol.7 (1), p.44103, Article 44103
Hauptverfasser:	Popovic, Ana, Hai, Tran, Tchigvintsev, Anatoly, Hajighasemi, Mahbod, Nocek, Boguslaw, Khusnutdinova, Anna N., Brown, Greg, Glinos, Julia, Flick, Robert, Skarina, Tatiana, Chernikova, Tatyana N., Yim, Veronica, Brüls, Thomas, Paslier, Denis Le, Yakimov, Michail M., Joachimiak, Andrzej, Ferrer, Manuel, Golyshina, Olga V., Savchenko, Alexei, Golyshin, Peter N., Yakunin, Alexander F.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/70 60 APPLIED LIFE SCIENCES 631/1647/2258/1266 631/45/607/1164 631/61/185 82 82/16 82/29 82/80 82/83 BASIC BIOLOGICAL SCIENCES Bioinformatics Carboxylesterase Carboxylic Ester Hydrolases - chemistry Carboxylic Ester Hydrolases - genetics Crystal structure Deoxyribonucleic acid Depolymerization DNA Environmental Microbiology Enzymes Escherichia coli - genetics Esterase expression systems Gene Library Humanities and Social Sciences hydrolases Life Sciences Lipase Metagenome Metagenomics multidisciplinary Polycaprolactone Polylactic acid Protein families Science Site-directed mutagenesis x-ray crystallography
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