Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa

Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colist...

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Veröffentlicht in:	BioMed research international 2017-01, Vol.2017 (2017), p.1-12
Hauptverfasser:	Yin, Jianhua, Qin, Wangrong, Zhu, Yuyi, Yu, Zhiliang, Qiu, Juanping
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Apoptosis Bacteria Care and treatment Colistin - pharmacology Deoxyribonucleic acid DNA Drug resistance in microorganisms Fermentation Gram-negative bacteria Gram-positive bacteria Lipids Oxidative stress Oxidative Stress - drug effects Paenibacillus polymyxa Paenibacillus polymyxa - metabolism Proteins
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