Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats
Background/Objectives: The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a sha...
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| Veröffentlicht in: | International Journal of Obesity 2017-03, Vol.41 (3), p.381-389 |
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| creator | Kim, T Holleman, C L Ptacek, T Morrow, C D Habegger, K M |
| description | Background/Objectives:
The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.
Methods:
We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake.
Results:
Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in
Paraprevotella
family members of the
Clostridiales
order along with an increase in
Akkermansia muciniphila
and species of the
Allobaculum
and
Bifidobacterium
genera.
Conclusions:
Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES. |
| doi_str_mv | 10.1038/ijo.2016.224 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5340580</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A484277317</galeid><sourcerecordid>A484277317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c707t-dd9c35fa50e298f72a9556f4a14da23219584c19b2fdba170ed85da7e923b36d3</originalsourceid><addsrcrecordid>eNqNks1rFDEYh4Modm29eZYBQTw423xOkotQ-qGFQi968RIyk3d2s8xMajJT8L83y9Y6K2UpOSTkffJ7SfIg9I7gJcFMnfpNWFJMqiWl_AVaEC6rUnAtX6IFZliWWFTiCL1JaYMxFgLT1-iISk05VnSBLi-m4GCwXQGDC93U--26tjF6iEXqAO6hsN0IMRWraSx638RQ-zDaIrTFz4urItoxnaBXre0SvH2Yj9GPq8vv59_Km9uv1-dnN2UjsRxL53TDRGsFBqpVK6nVQlQtt4Q7SxklWijeEF3T1tWWSAxOCWclaMpqVjl2jL7scu-mugfXwDBG25m76Hsbf5tgvdmvDH5tVuHeCMaxUDgHfHoIiOHXBGk0vU8NdJ0dIEzJECWlIgpL9gyUV5JozkVGP_yHbsIU80MmQysiBM0UPkTltlwSVVH6j1rZDowf2pAv0mxbm7NKaaqEYIcprjiVkhGZqeUTVB4O8j-GAVqf9_din3Vg3uHj7MAasinrlDUafRjSfvJBcJ74eQdmz1KK0D7-LsFmK7zJwput8CYLn_H3cyMe4b-GZ6DcASmXhhXE2as_FfgHQ-sEag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1874718622</pqid></control><display><type>article</type><title>Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Kim, T ; Holleman, C L ; Ptacek, T ; Morrow, C D ; Habegger, K M</creator><creatorcontrib>Kim, T ; Holleman, C L ; Ptacek, T ; Morrow, C D ; Habegger, K M</creatorcontrib><description>Background/Objectives:
The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.
Methods:
We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake.
Results:
Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in
Paraprevotella
family members of the
Clostridiales
order along with an increase in
Akkermansia muciniphila
and species of the
Allobaculum
and
Bifidobacterium
genera.
Conclusions:
Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2016.224</identifier><identifier>PMID: 27924082</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/41 ; 631/443/319/1642/2037 ; Animals ; Bifidobacterium ; Bioinformatics ; Body fat ; Body weight ; Body weight loss ; Care and treatment ; Cecum ; Clostridiales ; Comorbidity ; Complications and side effects ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - pathology ; Diet ; Disease Models, Animal ; Duodenum - surgery ; Dysbacteriosis ; Dysbiosis ; Dysbiosis - pathology ; Energy expenditure ; Epidemiology ; Etiology ; Food intake ; Gastric Bypass ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal surgery ; Glucose ; Glucose tolerance ; Health aspects ; Health Promotion and Disease Prevention ; Hindgut ; Hypoglycemic Agents - pharmacology ; Inflammation ; Internal Medicine ; Intestinal microflora ; Management ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Metformin ; Metformin - pharmacology ; Methods ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Obesity ; Obesity - pathology ; original-article ; Patient outcomes ; Prevention ; Public Health ; Rats ; Rats, Zucker ; Risk factors ; Rodents ; Taxonomy ; Type 2 diabetes ; Weight control ; Weight Loss ; Weight reduction</subject><ispartof>International Journal of Obesity, 2017-03, Vol.41 (3), p.381-389</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2017</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c707t-dd9c35fa50e298f72a9556f4a14da23219584c19b2fdba170ed85da7e923b36d3</citedby><cites>FETCH-LOGICAL-c707t-dd9c35fa50e298f72a9556f4a14da23219584c19b2fdba170ed85da7e923b36d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2016.224$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2016.224$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27924082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, T</creatorcontrib><creatorcontrib>Holleman, C L</creatorcontrib><creatorcontrib>Ptacek, T</creatorcontrib><creatorcontrib>Morrow, C D</creatorcontrib><creatorcontrib>Habegger, K M</creatorcontrib><title>Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives:
The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.
Methods:
We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake.
Results:
Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in
Paraprevotella
family members of the
Clostridiales
order along with an increase in
Akkermansia muciniphila
and species of the
Allobaculum
and
Bifidobacterium
genera.
Conclusions:
Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES.</description><subject>631/326/41</subject><subject>631/443/319/1642/2037</subject><subject>Animals</subject><subject>Bifidobacterium</subject><subject>Bioinformatics</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Care and treatment</subject><subject>Cecum</subject><subject>Clostridiales</subject><subject>Comorbidity</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Duodenum - surgery</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis</subject><subject>Dysbiosis - pathology</subject><subject>Energy expenditure</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Food intake</subject><subject>Gastric Bypass</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal surgery</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hindgut</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Intestinal microflora</subject><subject>Management</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Metformin</subject><subject>Metformin - pharmacology</subject><subject>Methods</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Microorganisms</subject><subject>Obesity</subject><subject>Obesity - pathology</subject><subject>original-article</subject><subject>Patient outcomes</subject><subject>Prevention</subject><subject>Public Health</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Taxonomy</subject><subject>Type 2 diabetes</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Weight reduction</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks1rFDEYh4Modm29eZYBQTw423xOkotQ-qGFQi968RIyk3d2s8xMajJT8L83y9Y6K2UpOSTkffJ7SfIg9I7gJcFMnfpNWFJMqiWl_AVaEC6rUnAtX6IFZliWWFTiCL1JaYMxFgLT1-iISk05VnSBLi-m4GCwXQGDC93U--26tjF6iEXqAO6hsN0IMRWraSx638RQ-zDaIrTFz4urItoxnaBXre0SvH2Yj9GPq8vv59_Km9uv1-dnN2UjsRxL53TDRGsFBqpVK6nVQlQtt4Q7SxklWijeEF3T1tWWSAxOCWclaMpqVjl2jL7scu-mugfXwDBG25m76Hsbf5tgvdmvDH5tVuHeCMaxUDgHfHoIiOHXBGk0vU8NdJ0dIEzJECWlIgpL9gyUV5JozkVGP_yHbsIU80MmQysiBM0UPkTltlwSVVH6j1rZDowf2pAv0mxbm7NKaaqEYIcprjiVkhGZqeUTVB4O8j-GAVqf9_din3Vg3uHj7MAasinrlDUafRjSfvJBcJ74eQdmz1KK0D7-LsFmK7zJwput8CYLn_H3cyMe4b-GZ6DcASmXhhXE2as_FfgHQ-sEag</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Kim, T</creator><creator>Holleman, C L</creator><creator>Ptacek, T</creator><creator>Morrow, C D</creator><creator>Habegger, K M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T7</scope><scope>7U2</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20170301</creationdate><title>Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats</title><author>Kim, T ; Holleman, C L ; Ptacek, T ; Morrow, C D ; Habegger, K M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c707t-dd9c35fa50e298f72a9556f4a14da23219584c19b2fdba170ed85da7e923b36d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/326/41</topic><topic>631/443/319/1642/2037</topic><topic>Animals</topic><topic>Bifidobacterium</topic><topic>Bioinformatics</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Care and treatment</topic><topic>Cecum</topic><topic>Clostridiales</topic><topic>Comorbidity</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Duodenum - surgery</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis</topic><topic>Dysbiosis - pathology</topic><topic>Energy expenditure</topic><topic>Epidemiology</topic><topic>Etiology</topic><topic>Food intake</topic><topic>Gastric Bypass</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal surgery</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hindgut</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Intestinal microflora</topic><topic>Management</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Metformin</topic><topic>Metformin - pharmacology</topic><topic>Methods</topic><topic>Microbiota</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Microorganisms</topic><topic>Obesity</topic><topic>Obesity - pathology</topic><topic>original-article</topic><topic>Patient outcomes</topic><topic>Prevention</topic><topic>Public Health</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Taxonomy</topic><topic>Type 2 diabetes</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, T</creatorcontrib><creatorcontrib>Holleman, C L</creatorcontrib><creatorcontrib>Ptacek, T</creatorcontrib><creatorcontrib>Morrow, C D</creatorcontrib><creatorcontrib>Habegger, K M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, T</au><au>Holleman, C L</au><au>Ptacek, T</au><au>Morrow, C D</au><au>Habegger, K M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>41</volume><issue>3</issue><spage>381</spage><epage>389</epage><pages>381-389</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objectives:
The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis.
Methods:
We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake.
Results:
Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in
Paraprevotella
family members of the
Clostridiales
order along with an increase in
Akkermansia muciniphila
and species of the
Allobaculum
and
Bifidobacterium
genera.
Conclusions:
Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27924082</pmid><doi>10.1038/ijo.2016.224</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International Journal of Obesity, 2017-03, Vol.41 (3), p.381-389 |
| issn | 0307-0565 1476-5497 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | 631/326/41 631/443/319/1642/2037 Animals Bifidobacterium Bioinformatics Body fat Body weight Body weight loss Care and treatment Cecum Clostridiales Comorbidity Complications and side effects Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - pathology Diet Disease Models, Animal Duodenum - surgery Dysbacteriosis Dysbiosis Dysbiosis - pathology Energy expenditure Epidemiology Etiology Food intake Gastric Bypass Gastrointestinal Microbiome - drug effects Gastrointestinal surgery Glucose Glucose tolerance Health aspects Health Promotion and Disease Prevention Hindgut Hypoglycemic Agents - pharmacology Inflammation Internal Medicine Intestinal microflora Management Medicine Medicine & Public Health Metabolic Diseases Metabolism Metformin Metformin - pharmacology Methods Microbiota Microbiota (Symbiotic organisms) Microorganisms Obesity Obesity - pathology original-article Patient outcomes Prevention Public Health Rats Rats, Zucker Risk factors Rodents Taxonomy Type 2 diabetes Weight control Weight Loss Weight reduction |
| title | Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats |
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