Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module
We report the development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry. The TW SLIM module was fabricated using two mirror-image printed circui...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2016-09, Vol.88 (18), p.8957-8964 |
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| creator | Deng, Liulin Ibrahim, Yehia M Hamid, Ahmed M Garimella, Sandilya V. B Webb, Ian K Zheng, Xueyun Prost, Spencer A Sandoval, Jeremy A Norheim, Randolph V Anderson, Gordon A Tolmachev, Aleksey V Baker, Erin S Smith, Richard D |
| description | We report the development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry. The TW SLIM module was fabricated using two mirror-image printed circuit boards with appropriately configured RF, DC, and TW electrodes and positioned with a 2.75 mm intersurface gap. Ions were effectively confined in field-generated conduits between the surfaces by RF-generated pseudopotential fields and moved losslessly through a serpentine path including 44 “U” turns using TWs. The ion mobility resolution was characterized at different pressures, gaps between the SLIM surfaces, and TW and RF parameters. After initial optimization, the SLIM IM-MS module provided about 5-fold higher resolution separations than present commercially available drift tube or traveling wave IM-MS platforms. Peak capacity and peak generation rates achieved were 246 and 370 s–1, respectively, at a TW speed of 148 m/s. The high resolution achieved in the TW SLIM IM-MS enabled, e.g., isomeric sugars (lacto-N-fucopentaose I and lacto-N-fucopentaose II) to be baseline resolved, and peptides from an albumin tryptic digest were much better resolved than with existing commercial IM-MS platforms. The present work also provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs. |
| doi_str_mv | 10.1021/acs.analchem.6b01915 |
| format | Article |
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B ; Webb, Ian K ; Zheng, Xueyun ; Prost, Spencer A ; Sandoval, Jeremy A ; Norheim, Randolph V ; Anderson, Gordon A ; Tolmachev, Aleksey V ; Baker, Erin S ; Smith, Richard D</creator><creatorcontrib>Deng, Liulin ; Ibrahim, Yehia M ; Hamid, Ahmed M ; Garimella, Sandilya V. B ; Webb, Ian K ; Zheng, Xueyun ; Prost, Spencer A ; Sandoval, Jeremy A ; Norheim, Randolph V ; Anderson, Gordon A ; Tolmachev, Aleksey V ; Baker, Erin S ; Smith, Richard D ; Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)</creatorcontrib><description>We report the development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry. The TW SLIM module was fabricated using two mirror-image printed circuit boards with appropriately configured RF, DC, and TW electrodes and positioned with a 2.75 mm intersurface gap. Ions were effectively confined in field-generated conduits between the surfaces by RF-generated pseudopotential fields and moved losslessly through a serpentine path including 44 “U” turns using TWs. The ion mobility resolution was characterized at different pressures, gaps between the SLIM surfaces, and TW and RF parameters. After initial optimization, the SLIM IM-MS module provided about 5-fold higher resolution separations than present commercially available drift tube or traveling wave IM-MS platforms. Peak capacity and peak generation rates achieved were 246 and 370 s–1, respectively, at a TW speed of 148 m/s. The high resolution achieved in the TW SLIM IM-MS enabled, e.g., isomeric sugars (lacto-N-fucopentaose I and lacto-N-fucopentaose II) to be baseline resolved, and peptides from an albumin tryptic digest were much better resolved than with existing commercial IM-MS platforms. The present work also provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs.</description><identifier>ISSN: 0003-2700</identifier><identifier>ISSN: 1520-6882</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.6b01915</identifier><identifier>PMID: 27531027</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>albumins ; Animals ; Cattle ; Electrodes ; Electromagnetic Phenomena ; Environmental Molecular Sciences Laboratory ; Equipment Design ; High resolution ; Ion mobility ; Ionic mobility ; Ions ; Ions - analysis ; Isomerism ; Lossless ; Mass spectrometry ; Mass Spectrometry - instrumentation ; Mass Spectrometry - methods ; Modules ; Oligosaccharides - analysis ; Oligosaccharides - chemistry ; Peptides ; Peptides - analysis ; Platforms ; Printed circuit boards ; Separation ; serpentine ; Serum Albumin, Bovine - chemistry ; spectroscopy ; sugars ; Traveling waves</subject><ispartof>Analytical chemistry (Washington), 2016-09, Vol.88 (18), p.8957-8964</ispartof><rights>Copyright © 2016 American Chemical Society</rights><rights>Copyright American Chemical Society Sep 20, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a607t-4a5632fe7450fbf668d33c656dd6236836dd83874caa598ffa5d7594c8678f433</citedby><cites>FETCH-LOGICAL-a607t-4a5632fe7450fbf668d33c656dd6236836dd83874caa598ffa5d7594c8678f433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b01915$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.6b01915$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,777,781,882,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27531027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1340773$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Liulin</creatorcontrib><creatorcontrib>Ibrahim, Yehia M</creatorcontrib><creatorcontrib>Hamid, Ahmed M</creatorcontrib><creatorcontrib>Garimella, Sandilya V. B</creatorcontrib><creatorcontrib>Webb, Ian K</creatorcontrib><creatorcontrib>Zheng, Xueyun</creatorcontrib><creatorcontrib>Prost, Spencer A</creatorcontrib><creatorcontrib>Sandoval, Jeremy A</creatorcontrib><creatorcontrib>Norheim, Randolph V</creatorcontrib><creatorcontrib>Anderson, Gordon A</creatorcontrib><creatorcontrib>Tolmachev, Aleksey V</creatorcontrib><creatorcontrib>Baker, Erin S</creatorcontrib><creatorcontrib>Smith, Richard D</creatorcontrib><creatorcontrib>Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)</creatorcontrib><title>Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>We report the development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry. The TW SLIM module was fabricated using two mirror-image printed circuit boards with appropriately configured RF, DC, and TW electrodes and positioned with a 2.75 mm intersurface gap. Ions were effectively confined in field-generated conduits between the surfaces by RF-generated pseudopotential fields and moved losslessly through a serpentine path including 44 “U” turns using TWs. The ion mobility resolution was characterized at different pressures, gaps between the SLIM surfaces, and TW and RF parameters. After initial optimization, the SLIM IM-MS module provided about 5-fold higher resolution separations than present commercially available drift tube or traveling wave IM-MS platforms. Peak capacity and peak generation rates achieved were 246 and 370 s–1, respectively, at a TW speed of 148 m/s. The high resolution achieved in the TW SLIM IM-MS enabled, e.g., isomeric sugars (lacto-N-fucopentaose I and lacto-N-fucopentaose II) to be baseline resolved, and peptides from an albumin tryptic digest were much better resolved than with existing commercial IM-MS platforms. The present work also provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs.</description><subject>albumins</subject><subject>Animals</subject><subject>Cattle</subject><subject>Electrodes</subject><subject>Electromagnetic Phenomena</subject><subject>Environmental Molecular Sciences Laboratory</subject><subject>Equipment Design</subject><subject>High resolution</subject><subject>Ion mobility</subject><subject>Ionic mobility</subject><subject>Ions</subject><subject>Ions - analysis</subject><subject>Isomerism</subject><subject>Lossless</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - instrumentation</subject><subject>Mass Spectrometry - methods</subject><subject>Modules</subject><subject>Oligosaccharides - analysis</subject><subject>Oligosaccharides - chemistry</subject><subject>Peptides</subject><subject>Peptides - analysis</subject><subject>Platforms</subject><subject>Printed circuit boards</subject><subject>Separation</subject><subject>serpentine</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>spectroscopy</subject><subject>sugars</subject><subject>Traveling waves</subject><issn>0003-2700</issn><issn>1520-6882</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1uEzEUhUcIREPhDRCyYMNmgv_tbJBQBbRSKhBtxNJyPJ7ElWMH21OpPApPi4dJy88CWFi-uv7uOZZ9muYpgnMEMXqlTZ7roL3Z2t2cryFaIHavmSGGYculxPebGYSQtFhAeNQ8yvkKQoQg4g-bIywYqSJi1nxb-ZJ0e-o2W_DJ5uiH4mIAZ3Wdx7XzrtyAC7vXSY_9DFal9r66sAGXSV9bP1afa5GBC0ADRMCu8mlvQ3HBgo-6bMHShk3dLkoaTBlSZfuYwDLm7G3Ok5cObj_4g8l57AZvHzcPeu2zfXLYj5vVu7eXJ6ft8sP7s5M3y1ZzKEpLNeME91ZQBvt1z7nsCDGc8a7jmHBJaiGJFNRozRay7zXrBFtQI7mQPSXkuHk96e6H9c52pl49aa_2ye10ulFRO_X7SXBbtYnXihEKKUZV4PkkEHNxKhtXrNmaGII1RaEKCTG6vDy4pPhlsLmoncvGeq-DjUNWePwsiKUU_0SRpExizgn6DxRjhKoqreiLP9CrOKQaoB8Uo4wSJCtFJ8qk-j_J9nfvgKAac6dq7tRt7tQhd3Xs2a9veDd0G7QKwAkYx38a_03zOwwj6DA</recordid><startdate>20160920</startdate><enddate>20160920</enddate><creator>Deng, Liulin</creator><creator>Ibrahim, Yehia M</creator><creator>Hamid, Ahmed M</creator><creator>Garimella, Sandilya V. B</creator><creator>Webb, Ian K</creator><creator>Zheng, Xueyun</creator><creator>Prost, Spencer A</creator><creator>Sandoval, Jeremy A</creator><creator>Norheim, Randolph V</creator><creator>Anderson, Gordon A</creator><creator>Tolmachev, Aleksey V</creator><creator>Baker, Erin S</creator><creator>Smith, Richard D</creator><general>American Chemical Society</general><general>American Chemical Society (ACS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20160920</creationdate><title>Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module</title><author>Deng, Liulin ; Ibrahim, Yehia M ; Hamid, Ahmed M ; Garimella, Sandilya V. 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B</au><au>Webb, Ian K</au><au>Zheng, Xueyun</au><au>Prost, Spencer A</au><au>Sandoval, Jeremy A</au><au>Norheim, Randolph V</au><au>Anderson, Gordon A</au><au>Tolmachev, Aleksey V</au><au>Baker, Erin S</au><au>Smith, Richard D</au><aucorp>Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2016-09-20</date><risdate>2016</risdate><volume>88</volume><issue>18</issue><spage>8957</spage><epage>8964</epage><pages>8957-8964</pages><issn>0003-2700</issn><issn>1520-6882</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>We report the development and initial evaluation of a 13 m path length Structures for Lossless Manipulations (SLIM) module for achieving high resolution separations using traveling waves (TW) with ion mobility (IM) spectrometry. The TW SLIM module was fabricated using two mirror-image printed circuit boards with appropriately configured RF, DC, and TW electrodes and positioned with a 2.75 mm intersurface gap. Ions were effectively confined in field-generated conduits between the surfaces by RF-generated pseudopotential fields and moved losslessly through a serpentine path including 44 “U” turns using TWs. The ion mobility resolution was characterized at different pressures, gaps between the SLIM surfaces, and TW and RF parameters. After initial optimization, the SLIM IM-MS module provided about 5-fold higher resolution separations than present commercially available drift tube or traveling wave IM-MS platforms. Peak capacity and peak generation rates achieved were 246 and 370 s–1, respectively, at a TW speed of 148 m/s. The high resolution achieved in the TW SLIM IM-MS enabled, e.g., isomeric sugars (lacto-N-fucopentaose I and lacto-N-fucopentaose II) to be baseline resolved, and peptides from an albumin tryptic digest were much better resolved than with existing commercial IM-MS platforms. The present work also provides a foundation for the development of much higher resolution SLIM devices based upon both considerably longer path lengths and multipass designs.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27531027</pmid><doi>10.1021/acs.analchem.6b01915</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Analytical chemistry (Washington), 2016-09, Vol.88 (18), p.8957-8964 |
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| subjects | albumins Animals Cattle Electrodes Electromagnetic Phenomena Environmental Molecular Sciences Laboratory Equipment Design High resolution Ion mobility Ionic mobility Ions Ions - analysis Isomerism Lossless Mass spectrometry Mass Spectrometry - instrumentation Mass Spectrometry - methods Modules Oligosaccharides - analysis Oligosaccharides - chemistry Peptides Peptides - analysis Platforms Printed circuit boards Separation serpentine Serum Albumin, Bovine - chemistry spectroscopy sugars Traveling waves |
| title | Ultra-High Resolution Ion Mobility Separations Utilizing Traveling Waves in a 13 m Serpentine Path Length Structures for Lossless Ion Manipulations Module |
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