FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells

Glioblastoma multiforme (GBM) continues to be the most frequently diagnosed and lethal primary brain tumor. Adjuvant chemo-radiotherapy remains the standard of care following surgical resection. In this study, using reverse phase protein arrays (RPPAs), we assessed the biological effects of radiatio...

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Veröffentlicht in:	Oncotarget 2016-11, Vol.7 (47), p.77365-77377
Hauptverfasser:	Maachani, Uday B, Shankavaram, Uma, Kramp, Tamalee, Tofilon, Philip J, Camphausen, Kevin, Tandle, Anita T
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Cell Cycle - drug effects Cell Cycle - genetics Cell Line, Tumor DNA Breaks, Double-Stranded DNA Repair Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - mortality Glioblastoma - radiotherapy Homologous Recombination Humans Kaplan-Meier Estimate Mitosis - drug effects Peptides - pharmacology Prognosis Protein Binding Protein Transport Proteome Proteomics - methods Radiation Tolerance - genetics Research Paper RNA Interference RNA, Small Interfering - genetics STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism
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