Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor

Extending the scope of biocatalysis to important non-natural reactions such as olefin cyclopropanation will open new opportunities for replacing multistep chemical syntheses of pharmaceutical intermediates with efficient, clean, and highly selective enzyme-catalyzed processes. In this work, we engin...

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Veröffentlicht in:	ACS catalysis 2016-11, Vol.6 (11), p.7810-7813
Hauptverfasser:	Hernandez, Kari E, Renata, Hans, Lewis, Russell D, Kan, S. B. Jennifer, Zhang, Chen, Forte, Jared, Rozzell, David, McIntosh, John A, Arnold, Frances H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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