Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

Despite ubiquitous activation in human cancer, essential downstream effector pathways of the MYC transcription factor have been difficult to define and target. Using a structure/function-based approach, we identified the mitochondrial RNA polymerase (POLRMT) locus as a critical downstream target of...

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Veröffentlicht in:	Oncotarget 2016-11, Vol.7 (45), p.72395-72414
Hauptverfasser:	Oran, Amanda R, Adams, Clare M, Zhang, Xiao-Yong, Gennaro, Victoria J, Pfeiffer, Harla K, Mellert, Hestia S, Seidel, Hans E, Mascioli, Kirsten, Kaplan, Jordan, Gaballa, Mahmoud R, Shen, Chen, Rigoutsos, Isidore, King, Michael P, Cotney, Justin L, Arnold, Jamie J, Sharma, Suresh D, Martinez-Outschoorn, Ubaldo E, Vakoc, Christopher R, Chodosh, Lewis A, Thompson, James E, Bradner, James E, Cameron, Craig E, Shadel, Gerald S, Eischen, Christine M, McMahon, Steven B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Female Gene Expression Regulation, Neoplastic Genes, Mitochondrial Genes, myc Humans Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria - genetics Mitochondria - metabolism Neoplasms - genetics Neoplasms - pathology Priority Research Paper Proto-Oncogene Proteins c-myc Reactive Oxygen Species - metabolism Transfection
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