Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A

Several NADPH oxidase family members, including dual oxidase 2 [DUOX2], are expressed in human tumors, particularly gastrointestinal cancers associated with long-standing chronic inflammation. We found previously that exposure of pancreatic ductal adenocarcinoma cells to the pro-inflammatory cytokin...

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Veröffentlicht in:	Oncotarget 2016-10, Vol.7 (42), p.68412-68433
Hauptverfasser:	Wu, Yongzhong, Meitzler, Jennifer L, Antony, Smitha, Juhasz, Agnes, Lu, Jiamo, Jiang, Guojian, Liu, Han, Hollingshead, Melinda, Haines, Diana C, Butcher, Donna, Panter, Michaela S, Roy, Krishnendu, Doroshow, James H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Cell Line, Tumor Dual Oxidases - antagonists & inhibitors Dual Oxidases - genetics Dual Oxidases - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic - drug effects HEK293 Cells Humans Hydrogen Peroxide - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Interferon-gamma - pharmacology Mice, Nude Onium Compounds - pharmacology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Research Paper RNA Interference Transplantation, Heterologous Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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