Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)
Entada abyssinica is a plant traditionally used against gastrointestinal bacterial infections. Eight compounds including three flavonoids, three terpenoids, a monoglyceride and a phenolic compound isolated from E. abyssinica were investigated for their cytotoxicity, antibacterial and antioxidant act...
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| creator | Dzoyem, Jean P Melong, Raduis Tsamo, Armelle T Tchinda, Alembert T Kapche, Deccaux G W F Ngadjui, Bonaventure T McGaw, Lyndy J Eloff, Jacobus N |
| description | Entada abyssinica is a plant traditionally used against gastrointestinal bacterial infections. Eight compounds including three flavonoids, three terpenoids, a monoglyceride and a phenolic compound isolated from E. abyssinica were investigated for their cytotoxicity, antibacterial and antioxidant activity.
Compounds 7 and 2 had remarkable activity against Salmonella typhimurium with the lowest respective minimum inhibitory concentration (MIC) values of 1.56 and 3.12 µg/mL. The antioxidant assay gave IC
values varied from 0.48 to 2.87 μg/mL in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, from 2.53 to 17.04 μg/mL in the 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assay and from 1.43 to 103.98 µg/mL in the FRAP assay. Compounds had relatively low cytotoxicity (LC
values ranging from 22.42 to 80.55 µg/mL) towards Vero cells. Ursolic acid had the most potent cytotoxicity against THP-1 and RAW 264.7 cells with LC
values of 9.62 and 4.56 μg/mL respectively, and selectivity index values of 7.32 and 15.44 respectively.
Our findings suggest that among the terpenoid and flavonoid compounds studied, entadanin (compound 7) possess tremendous antibacterial activity against S. typhimurium and could be developed for the treatment of bacterial diseases. |
| doi_str_mv | 10.1186/s13104-017-2441-z |
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Compounds 7 and 2 had remarkable activity against Salmonella typhimurium with the lowest respective minimum inhibitory concentration (MIC) values of 1.56 and 3.12 µg/mL. The antioxidant assay gave IC
values varied from 0.48 to 2.87 μg/mL in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, from 2.53 to 17.04 μg/mL in the 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assay and from 1.43 to 103.98 µg/mL in the FRAP assay. Compounds had relatively low cytotoxicity (LC
values ranging from 22.42 to 80.55 µg/mL) towards Vero cells. Ursolic acid had the most potent cytotoxicity against THP-1 and RAW 264.7 cells with LC
values of 9.62 and 4.56 μg/mL respectively, and selectivity index values of 7.32 and 15.44 respectively.
Our findings suggest that among the terpenoid and flavonoid compounds studied, entadanin (compound 7) possess tremendous antibacterial activity against S. typhimurium and could be developed for the treatment of bacterial diseases.</description><identifier>ISSN: 1756-0500</identifier><identifier>EISSN: 1756-0500</identifier><identifier>DOI: 10.1186/s13104-017-2441-z</identifier><identifier>PMID: 28264698</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Acids ; Africa ; Anti-Infective Agents - isolation & purification ; Anti-Infective Agents - pharmacology ; Antibacterial activity ; Antimicrobial agents ; Antioxidants ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Bacillus cereus - drug effects ; Bacteria ; Cancer ; Cell culture ; Cytotoxicity ; Cytotoxins - isolation & purification ; Cytotoxins - pharmacology ; Drugs ; Entada abyssinica ; Enterococcus faecalis - drug effects ; Escherichia coli - drug effects ; Fabaceae ; Flavonoids ; Food ; Free radicals ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; Leaves ; Microbial Sensitivity Tests ; Microorganisms ; Minimum inhibitory concentration ; Natural products ; Phenolic compounds ; Plant Bark ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves ; Plant Stems ; Plants, Medicinal ; Pseudomonas aeruginosa - drug effects ; Salmonella Typhimurium ; Salmonella typhimurium - drug effects ; Short Report ; Staphylococcus aureus - drug effects ; Ursolic acid ; Vero cells</subject><ispartof>BMC research notes, 2017-03, Vol.10 (1), p.118-118, Article 118</ispartof><rights>Copyright BioMed Central 2017</rights><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342z-d3515d3a7c8e0ddec61e151848f448f928d554f497ed8a62fca64b4b3016a083</citedby><cites>FETCH-LOGICAL-c342z-d3515d3a7c8e0ddec61e151848f448f928d554f497ed8a62fca64b4b3016a083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339975/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339975/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28264698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dzoyem, Jean P</creatorcontrib><creatorcontrib>Melong, Raduis</creatorcontrib><creatorcontrib>Tsamo, Armelle T</creatorcontrib><creatorcontrib>Tchinda, Alembert T</creatorcontrib><creatorcontrib>Kapche, Deccaux G W F</creatorcontrib><creatorcontrib>Ngadjui, Bonaventure T</creatorcontrib><creatorcontrib>McGaw, Lyndy J</creatorcontrib><creatorcontrib>Eloff, Jacobus N</creatorcontrib><title>Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)</title><title>BMC research notes</title><addtitle>BMC Res Notes</addtitle><description>Entada abyssinica is a plant traditionally used against gastrointestinal bacterial infections. Eight compounds including three flavonoids, three terpenoids, a monoglyceride and a phenolic compound isolated from E. abyssinica were investigated for their cytotoxicity, antibacterial and antioxidant activity.
Compounds 7 and 2 had remarkable activity against Salmonella typhimurium with the lowest respective minimum inhibitory concentration (MIC) values of 1.56 and 3.12 µg/mL. The antioxidant assay gave IC
values varied from 0.48 to 2.87 μg/mL in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, from 2.53 to 17.04 μg/mL in the 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assay and from 1.43 to 103.98 µg/mL in the FRAP assay. Compounds had relatively low cytotoxicity (LC
values ranging from 22.42 to 80.55 µg/mL) towards Vero cells. Ursolic acid had the most potent cytotoxicity against THP-1 and RAW 264.7 cells with LC
values of 9.62 and 4.56 μg/mL respectively, and selectivity index values of 7.32 and 15.44 respectively.
Our findings suggest that among the terpenoid and flavonoid compounds studied, entadanin (compound 7) possess tremendous antibacterial activity against S. typhimurium and could be developed for the treatment of bacterial diseases.</description><subject>Acids</subject><subject>Africa</subject><subject>Anti-Infective Agents - isolation & purification</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Bacillus cereus - drug effects</subject><subject>Bacteria</subject><subject>Cancer</subject><subject>Cell culture</subject><subject>Cytotoxicity</subject><subject>Cytotoxins - isolation & purification</subject><subject>Cytotoxins - pharmacology</subject><subject>Drugs</subject><subject>Entada abyssinica</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Escherichia coli - drug effects</subject><subject>Fabaceae</subject><subject>Flavonoids</subject><subject>Food</subject><subject>Free radicals</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Leaves</subject><subject>Microbial Sensitivity Tests</subject><subject>Microorganisms</subject><subject>Minimum inhibitory concentration</subject><subject>Natural products</subject><subject>Phenolic compounds</subject><subject>Plant Bark</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Plant Stems</subject><subject>Plants, Medicinal</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Salmonella Typhimurium</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Short Report</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Ursolic acid</subject><subject>Vero cells</subject><issn>1756-0500</issn><issn>1756-0500</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1P3DAQhi3UCijlB_RSWeqFSk3riT_iXCpVK2grIfXC3ZrYDhgl8TZ2ELu_Hi8LiPZgjcfzzivPPIR8APYVQKtvCTgwUTFoqloIqLYH5BgaqSomGXvz6n5E3qV0y5gCreGQHNW6VkK1-pjMq02OOd4HG_LmC8UphzHYOXYBh5K5x5dSdiVStDncFR2NPfXh-iZTG8d1XCaXaEhxwOwd7ec40vMpo0OK3SalMAWL9OwCO7Qe_ef35G2PQ_KnT_GEXF2cX61-VZd_fv5e_bisLBf1tnJcgnQcG6s9c85bBR4kaKF7UU5bayel6EXbeKdR1b1FJTrRcQYKmeYn5Pvedr10o3fWT3nGwaznMOK8MRGD-bcyhRtzHe-M5LxtG1kMzp4M5vh38SmbMSTrhwEnH5dkQDcSytqVKNJP_0lv4zJPZbqi0rwWhdbOEPaqst-UZt-_fAaY2QE1e6CmADU7oGZbej6-nuKl45kgfwDrIJ6N</recordid><startdate>20170306</startdate><enddate>20170306</enddate><creator>Dzoyem, Jean P</creator><creator>Melong, Raduis</creator><creator>Tsamo, Armelle T</creator><creator>Tchinda, Alembert T</creator><creator>Kapche, Deccaux G W F</creator><creator>Ngadjui, Bonaventure T</creator><creator>McGaw, Lyndy J</creator><creator>Eloff, Jacobus N</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170306</creationdate><title>Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)</title><author>Dzoyem, Jean P ; Melong, Raduis ; Tsamo, Armelle T ; Tchinda, Alembert T ; Kapche, Deccaux G W F ; Ngadjui, Bonaventure T ; McGaw, Lyndy J ; Eloff, Jacobus N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342z-d3515d3a7c8e0ddec61e151848f448f928d554f497ed8a62fca64b4b3016a083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Africa</topic><topic>Anti-Infective Agents - isolation & purification</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Bacillus cereus - drug effects</topic><topic>Bacteria</topic><topic>Cancer</topic><topic>Cell culture</topic><topic>Cytotoxicity</topic><topic>Cytotoxins - isolation & purification</topic><topic>Cytotoxins - pharmacology</topic><topic>Drugs</topic><topic>Entada abyssinica</topic><topic>Enterococcus faecalis - drug effects</topic><topic>Escherichia coli - drug effects</topic><topic>Fabaceae</topic><topic>Flavonoids</topic><topic>Food</topic><topic>Free radicals</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Leaves</topic><topic>Microbial Sensitivity Tests</topic><topic>Microorganisms</topic><topic>Minimum inhibitory concentration</topic><topic>Natural products</topic><topic>Phenolic compounds</topic><topic>Plant Bark</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Plant Stems</topic><topic>Plants, Medicinal</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Salmonella Typhimurium</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Short Report</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Ursolic acid</topic><topic>Vero cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dzoyem, Jean P</creatorcontrib><creatorcontrib>Melong, Raduis</creatorcontrib><creatorcontrib>Tsamo, Armelle T</creatorcontrib><creatorcontrib>Tchinda, Alembert T</creatorcontrib><creatorcontrib>Kapche, Deccaux G W F</creatorcontrib><creatorcontrib>Ngadjui, Bonaventure T</creatorcontrib><creatorcontrib>McGaw, Lyndy J</creatorcontrib><creatorcontrib>Eloff, Jacobus N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC research notes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dzoyem, Jean P</au><au>Melong, Raduis</au><au>Tsamo, Armelle T</au><au>Tchinda, Alembert T</au><au>Kapche, Deccaux G W F</au><au>Ngadjui, Bonaventure T</au><au>McGaw, Lyndy J</au><au>Eloff, Jacobus N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)</atitle><jtitle>BMC research notes</jtitle><addtitle>BMC Res Notes</addtitle><date>2017-03-06</date><risdate>2017</risdate><volume>10</volume><issue>1</issue><spage>118</spage><epage>118</epage><pages>118-118</pages><artnum>118</artnum><issn>1756-0500</issn><eissn>1756-0500</eissn><abstract>Entada abyssinica is a plant traditionally used against gastrointestinal bacterial infections. Eight compounds including three flavonoids, three terpenoids, a monoglyceride and a phenolic compound isolated from E. abyssinica were investigated for their cytotoxicity, antibacterial and antioxidant activity.
Compounds 7 and 2 had remarkable activity against Salmonella typhimurium with the lowest respective minimum inhibitory concentration (MIC) values of 1.56 and 3.12 µg/mL. The antioxidant assay gave IC
values varied from 0.48 to 2.87 μg/mL in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, from 2.53 to 17.04 μg/mL in the 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assay and from 1.43 to 103.98 µg/mL in the FRAP assay. Compounds had relatively low cytotoxicity (LC
values ranging from 22.42 to 80.55 µg/mL) towards Vero cells. Ursolic acid had the most potent cytotoxicity against THP-1 and RAW 264.7 cells with LC
values of 9.62 and 4.56 μg/mL respectively, and selectivity index values of 7.32 and 15.44 respectively.
Our findings suggest that among the terpenoid and flavonoid compounds studied, entadanin (compound 7) possess tremendous antibacterial activity against S. typhimurium and could be developed for the treatment of bacterial diseases.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28264698</pmid><doi>10.1186/s13104-017-2441-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Africa Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Antibacterial activity Antimicrobial agents Antioxidants Antioxidants - isolation & purification Antioxidants - pharmacology Bacillus cereus - drug effects Bacteria Cancer Cell culture Cytotoxicity Cytotoxins - isolation & purification Cytotoxins - pharmacology Drugs Entada abyssinica Enterococcus faecalis - drug effects Escherichia coli - drug effects Fabaceae Flavonoids Food Free radicals Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Leaves Microbial Sensitivity Tests Microorganisms Minimum inhibitory concentration Natural products Phenolic compounds Plant Bark Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves Plant Stems Plants, Medicinal Pseudomonas aeruginosa - drug effects Salmonella Typhimurium Salmonella typhimurium - drug effects Short Report Staphylococcus aureus - drug effects Ursolic acid Vero cells |
| title | Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae) |
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