Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

Autophagy requires diverse membrane sources and involves membrane trafficking of mATG9, the only membrane protein in the ATG family. However, the molecular regulation of mATG9 trafficking for autophagy initiation remains unclear. Here we identified two conserved classic adaptor protein sorting signa...

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Veröffentlicht in:	Cell research 2017-02, Vol.27 (2), p.184-201
Hauptverfasser:	Zhou, Changqian, Ma, Kaili, Gao, Ruize, Mu, Chenglong, Chen, Linbo, Liu, Qiangqiang, Luo, Qian, Feng, Du, Zhu, Yushan, Chen, Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/313 631/80/458/1733 631/80/82/39 631/80/86 Amino Acid Sequence Autophagy - drug effects Autophagy-Related Protein-1 Homolog - metabolism Autophagy-Related Proteins - chemistry Autophagy-Related Proteins - metabolism Biomedical and Life Sciences Cell Biology Cell Membrane - metabolism Conserved Sequence Epidermal Growth Factor - pharmacology HEK293 Cells HeLa Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Original original-article Phosphorylation - drug effects Phosphotyrosine - metabolism Protein Transport - drug effects src-Family Kinases - metabolism Starvation - metabolism Starvation - pathology Stress, Physiological - drug effects Vesicular Transport Proteins - chemistry Vesicular Transport Proteins - metabolism
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