Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte

The irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger. Here we identified the...

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Veröffentlicht in:	Scientific reports 2017-03, Vol.7 (1), p.43921-43921, Article 43921
Hauptverfasser:	Sasaki, Yu, Hidaka, Teruo, Ueno, Takashi, Akiba-Takagi, Miyuki, Oliva Trejo, Juan Alejandro, Seki, Takuto, Nagai-Hosoe, Yoshiko, Tanaka, Eriko, Horikoshi, Satoshi, Tomino, Yasuhiko, Suzuki, Yusuke, Asanuma, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 14/19 38/109 38/111 38/89 631/45/612/1237 631/80/313/1461 64/60 692/4022/1585/2759 692/4022/272/1684/1587/2101 82/29 82/80 Actin Animals Biopsy Clathrin Disease Models, Animal Endocytosis Glomerulonephritis, IGA - pathology Glomerulonephritis, Membranous - pathology Glomerulosclerosis, Focal Segmental - pathology Humanities and Social Sciences Humans IgA nephropathy Immunofluorescence Immunoglobulin A Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism Localization Membrane Proteins - metabolism Membranous nephropathy Mice, Inbred BALB C multidisciplinary Nexin Podocytes - metabolism Protein Binding Protein Interaction Mapping Protein transport Rodents Science Sorting Nexins - metabolism Translocation Two-Hybrid System Techniques Yeasts
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