Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat
This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) eith...
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| Veröffentlicht in: | Scientific reports 2017-03, Vol.7 (1), p.43300-43300, Article 43300 |
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| creator | Patterson, Elaine Wall, Rebecca Lisai, Sara Ross, R. Paul Dinan, Timothy G. Cryan, John F. Fitzgerald, Gerald F. Banni, Sebastiano Quigley, Eamonn M. Shanahan, Fergus Stanton, Catherine |
| description | This study focused on the mechanisms that fatty acid conjugating strains -
Bifidobacterium breve
NCIMB 702258 and
Bifidobacterium breve
DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with
B. breve
NCIMB 702258 or
B. breve
DPC 6330 (10
9
CFU/day) or unsupplemented control diet for six weeks. The overall
n
-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with
B. breve (P
|
| doi_str_mv | 10.1038/srep43300 |
| format | Article |
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Bifidobacterium breve
NCIMB 702258 and
Bifidobacterium breve
DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with
B. breve
NCIMB 702258 or
B. breve
DPC 6330 (10
9
CFU/day) or unsupplemented control diet for six weeks. The overall
n
-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with
B. breve (P
< 0.05) and so the ability of the strains to produce
c
9
t
11 conjuga
t
ed linoleic acid (CLA) was identified in adipose tissue. Furthermore, a strain specific effect of
B. breve
NCIMB 702258 was found on the endocannabinoid system (ECS). Liver triglycerides (TAG) were reduced following ALA supplementation, compared with unsupplemented controls (
P
< 0.01) while intervention with
B. breve
further reduced liver TAG (
P
< 0.01), compared with the ALA enriched control. These data indicate that the interactions of the gut microbiota with fatty acid metabolism directly affect host health by modulating
n
-3 PUFA score and the ECS.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep43300</identifier><identifier>PMID: 28265110</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 38/90 ; 631/326/107 ; 631/326/2522 ; 64/60 ; 692/308/1426 ; Astrophysics ; Humanities and Social Sciences ; multidisciplinary ; Physics ; Science</subject><ispartof>Scientific reports, 2017-03, Vol.7 (1), p.43300-43300, Article 43300</ispartof><rights>The Author(s) 2017</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-58edd7cad8127b65d10ad8f5bf3899a441acbbdc552588bdd453673f45b08e0e3</citedby><cites>FETCH-LOGICAL-c444t-58edd7cad8127b65d10ad8f5bf3899a441acbbdc552588bdd453673f45b08e0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339701/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339701/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28265110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03742807$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Patterson, Elaine</creatorcontrib><creatorcontrib>Wall, Rebecca</creatorcontrib><creatorcontrib>Lisai, Sara</creatorcontrib><creatorcontrib>Ross, R. Paul</creatorcontrib><creatorcontrib>Dinan, Timothy G.</creatorcontrib><creatorcontrib>Cryan, John F.</creatorcontrib><creatorcontrib>Fitzgerald, Gerald F.</creatorcontrib><creatorcontrib>Banni, Sebastiano</creatorcontrib><creatorcontrib>Quigley, Eamonn M.</creatorcontrib><creatorcontrib>Shanahan, Fergus</creatorcontrib><creatorcontrib>Stanton, Catherine</creatorcontrib><title>Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study focused on the mechanisms that fatty acid conjugating strains -
Bifidobacterium breve
NCIMB 702258 and
Bifidobacterium breve
DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with
B. breve
NCIMB 702258 or
B. breve
DPC 6330 (10
9
CFU/day) or unsupplemented control diet for six weeks. The overall
n
-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with
B. breve (P
< 0.05) and so the ability of the strains to produce
c
9
t
11 conjuga
t
ed linoleic acid (CLA) was identified in adipose tissue. Furthermore, a strain specific effect of
B. breve
NCIMB 702258 was found on the endocannabinoid system (ECS). Liver triglycerides (TAG) were reduced following ALA supplementation, compared with unsupplemented controls (
P
< 0.01) while intervention with
B. breve
further reduced liver TAG (
P
< 0.01), compared with the ALA enriched control. These data indicate that the interactions of the gut microbiota with fatty acid metabolism directly affect host health by modulating
n
-3 PUFA score and the ECS.</description><subject>38/39</subject><subject>38/90</subject><subject>631/326/107</subject><subject>631/326/2522</subject><subject>64/60</subject><subject>692/308/1426</subject><subject>Astrophysics</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Physics</subject><subject>Science</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNptkktuFDEQhlsIRKKQBRdAXgKiwc9p9wYpRECQRmIDa8uvzlTUbQ-2e6LchwtwEc6EJx2GgPDG5aq_vlK5qmmeEvyaYCbf5OS3nDGMHzTHFHPRUkbpw3v2UXOa8xWuR9Cek_5xc0QlXQlC8HHz_R0M4KLRtvgE84RM8juPrqFs0M8f7Qghjj6ARdqCQ3qsqozKxiMbp23MUCCGV8hBLgnMvH8hHRwqSYdsE2xvPUOlx1QRBXZQbpDOOVrQxbul0OSLNnGEPN0ma5NjWjLjUJPLk-bRoMfsT-_uk-brh_dfzi_a9eePn87P1q3lnJdWSO9cZ7WThHZmJRzB1R6EGZjse8050dYYZ4WgQkrjHBds1bGBC4Olx56dNG8X7nY2k3fWh9rHqLYJJp1uVNSg_o4E2KjLuFOCsb7DpAJeLIDNP2kXZ2u192HWcSpxt9trn98VS_Hb7HNRE2Trx1EHH-esiOwE4RT3_A_WppjrvIcDm2C1XwJ1WIKqfXa_h4Py98ir4OUiyDUULn1SV3FOof7rf2i_AH90wY0</recordid><startdate>20170307</startdate><enddate>20170307</enddate><creator>Patterson, Elaine</creator><creator>Wall, Rebecca</creator><creator>Lisai, Sara</creator><creator>Ross, R. Paul</creator><creator>Dinan, Timothy G.</creator><creator>Cryan, John F.</creator><creator>Fitzgerald, Gerald F.</creator><creator>Banni, Sebastiano</creator><creator>Quigley, Eamonn M.</creator><creator>Shanahan, Fergus</creator><creator>Stanton, Catherine</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>20170307</creationdate><title>Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat</title><author>Patterson, Elaine ; Wall, Rebecca ; Lisai, Sara ; Ross, R. Paul ; Dinan, Timothy G. ; Cryan, John F. ; Fitzgerald, Gerald F. ; Banni, Sebastiano ; Quigley, Eamonn M. ; Shanahan, Fergus ; Stanton, Catherine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-58edd7cad8127b65d10ad8f5bf3899a441acbbdc552588bdd453673f45b08e0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>38/39</topic><topic>38/90</topic><topic>631/326/107</topic><topic>631/326/2522</topic><topic>64/60</topic><topic>692/308/1426</topic><topic>Astrophysics</topic><topic>Humanities and Social Sciences</topic><topic>multidisciplinary</topic><topic>Physics</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patterson, Elaine</creatorcontrib><creatorcontrib>Wall, Rebecca</creatorcontrib><creatorcontrib>Lisai, Sara</creatorcontrib><creatorcontrib>Ross, R. Paul</creatorcontrib><creatorcontrib>Dinan, Timothy G.</creatorcontrib><creatorcontrib>Cryan, John F.</creatorcontrib><creatorcontrib>Fitzgerald, Gerald F.</creatorcontrib><creatorcontrib>Banni, Sebastiano</creatorcontrib><creatorcontrib>Quigley, Eamonn M.</creatorcontrib><creatorcontrib>Shanahan, Fergus</creatorcontrib><creatorcontrib>Stanton, Catherine</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patterson, Elaine</au><au>Wall, Rebecca</au><au>Lisai, Sara</au><au>Ross, R. Paul</au><au>Dinan, Timothy G.</au><au>Cryan, John F.</au><au>Fitzgerald, Gerald F.</au><au>Banni, Sebastiano</au><au>Quigley, Eamonn M.</au><au>Shanahan, Fergus</au><au>Stanton, Catherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-03-07</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>43300</spage><epage>43300</epage><pages>43300-43300</pages><artnum>43300</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study focused on the mechanisms that fatty acid conjugating strains -
Bifidobacterium breve
NCIMB 702258 and
Bifidobacterium breve
DPC 6330 - influence lipid metabolism when ingested with α-linolenic acid (ALA) enriched diet. Four groups of BALB/c mice received ALA enriched diet (3% (w/w)) either alone or in combination with
B. breve
NCIMB 702258 or
B. breve
DPC 6330 (10
9
CFU/day) or unsupplemented control diet for six weeks. The overall
n
-3 PUFA score was increased in all groups receiving the ALA enriched diet. Hepatic peroxisomal beta oxidation increased following supplementation of the ALA enriched diet with
B. breve (P
< 0.05) and so the ability of the strains to produce
c
9
t
11 conjuga
t
ed linoleic acid (CLA) was identified in adipose tissue. Furthermore, a strain specific effect of
B. breve
NCIMB 702258 was found on the endocannabinoid system (ECS). Liver triglycerides (TAG) were reduced following ALA supplementation, compared with unsupplemented controls (
P
< 0.01) while intervention with
B. breve
further reduced liver TAG (
P
< 0.01), compared with the ALA enriched control. These data indicate that the interactions of the gut microbiota with fatty acid metabolism directly affect host health by modulating
n
-3 PUFA score and the ECS.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28265110</pmid><doi>10.1038/srep43300</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 38/39 38/90 631/326/107 631/326/2522 64/60 692/308/1426 Astrophysics Humanities and Social Sciences multidisciplinary Physics Science |
| title | Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat |
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