Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs
Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%...
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| Veröffentlicht in: | Molecular psychiatry 2017-05, Vol.22 (5), p.774-783 |
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| creator | Wingo, A P Almli, L M Stevens, J S Jovanovic, T Wingo, T S Tharp, G Li, Y Lori, A Briscione, M Jin, P Binder, E B Bradley, B Gibson, G Ressler, K J |
| description | Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%, positive affect is substantially influenced by genetic factors; however, our understanding of genetic pathways underlying individual differences in positive affect is still limited. Here, through a genome-wide association study of positive affect in African-American participants, we identify a single-nucleotide polymorphism, rs322931, significantly associated with positive affect at
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| doi_str_mv | 10.1038/mp.2016.143 |
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P
<5 × 10
−8
, and replicate this association in another cohort. Furthermore, we show that the minor allele of rs322931 predicts expression of microRNAs miR-181a and miR-181b in human brain and blood, greater nucleus accumbens reactivity to positive emotional stimuli and enhanced fear inhibition. Prior studies have suggested that miR-181a is part of the reward neurocircuitry. Taken together, we identify a novel genetic variant for further elucidation of genetic underpinning of positive affect that mediates positive emotionality potentially via the nucleus accumbens and miR-181.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/mp.2016.143</identifier><identifier>PMID: 27595594</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/43 ; 631/208 ; 631/337 ; 631/378 ; Adult ; African Americans ; Alleles ; Behavioral Sciences ; Biological Psychology ; Black or African American - genetics ; Chromosomes, Human, Pair 1 ; Emotions ; Emotions - physiology ; Female ; Gene Frequency ; Genetic diversity ; Genetic factors ; Genetic Variation ; Genome-wide association studies ; Genome-Wide Association Study - methods ; Genomes ; Happiness ; Heritability ; Humans ; Introns ; Longitudinal studies ; Male ; Medicine ; Medicine & Public Health ; MicroRNAs ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Neurosciences ; Nucleus accumbens ; original-article ; Pharmacotherapy ; Pleasure - physiology ; Polymorphism ; Polymorphism, Single Nucleotide ; Psychiatry ; Reinforcement ; Single-nucleotide polymorphism</subject><ispartof>Molecular psychiatry, 2017-05, Vol.22 (5), p.774-783</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2016</rights><rights>Copyright Nature Publishing Group May 2017</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-c59d95e2f623f73ae9a7935e267b9336957afd39f57098bf9822636001a202043</citedby><cites>FETCH-LOGICAL-c507t-c59d95e2f623f73ae9a7935e267b9336957afd39f57098bf9822636001a202043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/mp.2016.143$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/mp.2016.143$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27595594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wingo, A P</creatorcontrib><creatorcontrib>Almli, L M</creatorcontrib><creatorcontrib>Stevens, J S</creatorcontrib><creatorcontrib>Jovanovic, T</creatorcontrib><creatorcontrib>Wingo, T S</creatorcontrib><creatorcontrib>Tharp, G</creatorcontrib><creatorcontrib>Li, Y</creatorcontrib><creatorcontrib>Lori, A</creatorcontrib><creatorcontrib>Briscione, M</creatorcontrib><creatorcontrib>Jin, P</creatorcontrib><creatorcontrib>Binder, E B</creatorcontrib><creatorcontrib>Bradley, B</creatorcontrib><creatorcontrib>Gibson, G</creatorcontrib><creatorcontrib>Ressler, K J</creatorcontrib><title>Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%, positive affect is substantially influenced by genetic factors; however, our understanding of genetic pathways underlying individual differences in positive affect is still limited. Here, through a genome-wide association study of positive affect in African-American participants, we identify a single-nucleotide polymorphism, rs322931, significantly associated with positive affect at
P
<5 × 10
−8
, and replicate this association in another cohort. Furthermore, we show that the minor allele of rs322931 predicts expression of microRNAs miR-181a and miR-181b in human brain and blood, greater nucleus accumbens reactivity to positive emotional stimuli and enhanced fear inhibition. Prior studies have suggested that miR-181a is part of the reward neurocircuitry. Taken together, we identify a novel genetic variant for further elucidation of genetic underpinning of positive affect that mediates positive emotionality potentially via the nucleus accumbens and miR-181.</description><subject>38/43</subject><subject>631/208</subject><subject>631/337</subject><subject>631/378</subject><subject>Adult</subject><subject>African Americans</subject><subject>Alleles</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Black or African American - genetics</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Emotions</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic diversity</subject><subject>Genetic factors</subject><subject>Genetic Variation</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genomes</subject><subject>Happiness</subject><subject>Heritability</subject><subject>Humans</subject><subject>Introns</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>MicroRNAs</subject><subject>MicroRNAs - biosynthesis</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Neurosciences</subject><subject>Nucleus accumbens</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Pleasure - physiology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatry</subject><subject>Reinforcement</subject><subject>Single-nucleotide polymorphism</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks1rFTEUxYMotlZX7iXgRtB55mPytSmUolUoCqLrkDdz80yZScZk5kn_ezO-WqqIuEnCPT_Ozb0chJ5SsqGE69fjtGGEyg1t-T10TFslGyGUvl_fXJimpbo9Qo9KuSJkFcVDdMSUMEKY9hjtLiCmEZrvoQfsSkldcHNIEZd56a9x8nhKJcxhDxjG9FOpZJyDD1CwwzuIMIcO710OLs7Yxb5WcxoA-5TxGLqcPn04K4_RA--GAk9u7hP05e2bz-fvmsuPF-_Pzy6bThA119P0RgDzknGvuAPjlOG1INXWcC6NUM733HihiNFbbzRjkss6mWOEkZafoNOD77RsR-i7-tXsBjvlMLp8bZML9nclhq92l_ZWcG6IotXgxY1BTt8WKLMdQ-lgGFyEtBRLtVEradr_QLmQmrd6RZ__gV6lJce6CcskFYJTxfW_qNqWUGJaKir18kDV1ZaSwd9OR4ldE2HHya6JsDURlX52dyG37K8IVODVAShVijvId5r-xe8H3n6-cQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Wingo, A P</creator><creator>Almli, L M</creator><creator>Stevens, J S</creator><creator>Jovanovic, T</creator><creator>Wingo, T S</creator><creator>Tharp, G</creator><creator>Li, Y</creator><creator>Lori, A</creator><creator>Briscione, M</creator><creator>Jin, P</creator><creator>Binder, E B</creator><creator>Bradley, B</creator><creator>Gibson, G</creator><creator>Ressler, K J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170501</creationdate><title>Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs</title><author>Wingo, A P ; Almli, L M ; Stevens, J S ; Jovanovic, T ; Wingo, T S ; Tharp, G ; Li, Y ; Lori, A ; Briscione, M ; Jin, P ; Binder, E B ; Bradley, B ; Gibson, G ; Ressler, K J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-c59d95e2f623f73ae9a7935e267b9336957afd39f57098bf9822636001a202043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>38/43</topic><topic>631/208</topic><topic>631/337</topic><topic>631/378</topic><topic>Adult</topic><topic>African Americans</topic><topic>Alleles</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Black or African American - genetics</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Emotions</topic><topic>Emotions - physiology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic diversity</topic><topic>Genetic factors</topic><topic>Genetic Variation</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study - methods</topic><topic>Genomes</topic><topic>Happiness</topic><topic>Heritability</topic><topic>Humans</topic><topic>Introns</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>MicroRNAs</topic><topic>MicroRNAs - biosynthesis</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Neurosciences</topic><topic>Nucleus accumbens</topic><topic>original-article</topic><topic>Pharmacotherapy</topic><topic>Pleasure - physiology</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychiatry</topic><topic>Reinforcement</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wingo, A P</creatorcontrib><creatorcontrib>Almli, L M</creatorcontrib><creatorcontrib>Stevens, J S</creatorcontrib><creatorcontrib>Jovanovic, T</creatorcontrib><creatorcontrib>Wingo, T S</creatorcontrib><creatorcontrib>Tharp, G</creatorcontrib><creatorcontrib>Li, Y</creatorcontrib><creatorcontrib>Lori, A</creatorcontrib><creatorcontrib>Briscione, M</creatorcontrib><creatorcontrib>Jin, P</creatorcontrib><creatorcontrib>Binder, E B</creatorcontrib><creatorcontrib>Bradley, B</creatorcontrib><creatorcontrib>Gibson, G</creatorcontrib><creatorcontrib>Ressler, K J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wingo, A P</au><au>Almli, L M</au><au>Stevens, J S</au><au>Jovanovic, T</au><au>Wingo, T S</au><au>Tharp, G</au><au>Li, Y</au><au>Lori, A</au><au>Briscione, M</au><au>Jin, P</au><au>Binder, E B</au><au>Bradley, B</au><au>Gibson, G</au><au>Ressler, K J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>22</volume><issue>5</issue><spage>774</spage><epage>783</epage><pages>774-783</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%, positive affect is substantially influenced by genetic factors; however, our understanding of genetic pathways underlying individual differences in positive affect is still limited. Here, through a genome-wide association study of positive affect in African-American participants, we identify a single-nucleotide polymorphism, rs322931, significantly associated with positive affect at
P
<5 × 10
−8
, and replicate this association in another cohort. Furthermore, we show that the minor allele of rs322931 predicts expression of microRNAs miR-181a and miR-181b in human brain and blood, greater nucleus accumbens reactivity to positive emotional stimuli and enhanced fear inhibition. Prior studies have suggested that miR-181a is part of the reward neurocircuitry. Taken together, we identify a novel genetic variant for further elucidation of genetic underpinning of positive affect that mediates positive emotionality potentially via the nucleus accumbens and miR-181.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27595594</pmid><doi>10.1038/mp.2016.143</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular psychiatry, 2017-05, Vol.22 (5), p.774-783 |
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| subjects | 38/43 631/208 631/337 631/378 Adult African Americans Alleles Behavioral Sciences Biological Psychology Black or African American - genetics Chromosomes, Human, Pair 1 Emotions Emotions - physiology Female Gene Frequency Genetic diversity Genetic factors Genetic Variation Genome-wide association studies Genome-Wide Association Study - methods Genomes Happiness Heritability Humans Introns Longitudinal studies Male Medicine Medicine & Public Health MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics Middle Aged miRNA Neurosciences Nucleus accumbens original-article Pharmacotherapy Pleasure - physiology Polymorphism Polymorphism, Single Nucleotide Psychiatry Reinforcement Single-nucleotide polymorphism |
| title | Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs |
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