miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma
An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles...
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| Veröffentlicht in: | OncoTargets and therapy 2017-01, Vol.10, p.1237-1246 |
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| creator | Luan, Wenkang Qian, Yao Ni, Xin Bu, Xuefeng Xia, Yun Wang, Jinlong Ruan, Hongru Ma, Shaojun Xu, Bin |
| description | An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma. |
| doi_str_mv | 10.2147/OTT.S128819 |
| format | Article |
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In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S128819</identifier><identifier>PMID: 28280358</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>5-Fluorouracil ; Analysis ; Apoptosis ; Care and treatment ; Cell adhesion & migration ; Cell cycle ; Cell growth ; Development and progression ; Gene expression ; Health aspects ; Lymphoma ; Medical prognosis ; Melanoma ; Metastasis ; MicroRNA ; MicroRNAs ; Original Research ; Physiological aspects ; Plasmids ; Prognosis ; Prostate cancer ; Skin cancer ; Surgery ; Tumor suppressor genes ; Tumorigenesis ; Xenografts ; Zinc finger proteins</subject><ispartof>OncoTargets and therapy, 2017-01, Vol.10, p.1237-1246</ispartof><rights>COPYRIGHT 2017 Dove Medical Press Limited</rights><rights>2017. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Luan et al. This work is published and licensed by Dove Medical Press Limited 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-d49fb2f110c7717f8fcae65e315e38a62d2764edcf2239d3cecdafb7092f7c743</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338948/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338948/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3849,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28280358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luan, Wenkang</creatorcontrib><creatorcontrib>Qian, Yao</creatorcontrib><creatorcontrib>Ni, Xin</creatorcontrib><creatorcontrib>Bu, Xuefeng</creatorcontrib><creatorcontrib>Xia, Yun</creatorcontrib><creatorcontrib>Wang, Jinlong</creatorcontrib><creatorcontrib>Ruan, Hongru</creatorcontrib><creatorcontrib>Ma, Shaojun</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><title>miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma.</description><subject>5-Fluorouracil</subject><subject>Analysis</subject><subject>Apoptosis</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Original Research</subject><subject>Physiological aspects</subject><subject>Plasmids</subject><subject>Prognosis</subject><subject>Prostate cancer</subject><subject>Skin cancer</subject><subject>Surgery</subject><subject>Tumor suppressor genes</subject><subject>Tumorigenesis</subject><subject>Xenografts</subject><subject>Zinc finger proteins</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkttrFDEUxgdRbK0--S4BQQoya24zybwUavEGhYKuzyGbSXZTchmTjLj9683Ste6KJCGHk9_3JSecpnmJ4AIjyt7dLJeLbwhzjoZHzSlCjLf9QODjg_ikeZbzLYR9zzF92pxgjjkkHT9t7rz92mJI224CUpUMZJ2gzD4mkOdpSjrnGq62oMi01sWGNfCyJPsLeF2kc3FKsWgbZNa5HYAMI3jfKu0ccFs_baKXLQY2VJGz6yBDqTonQ80_b54Y6bJ-sd_Pmu8fPyyvPrfXN5--XF1et6pjpLQjHcwKG4SgYgwxw42Suu80QXVx2eMRs57qURmMyTASpdUozYrBARumGCVnzcW97zSvfOV0KEk6MSXrZdqKKK04Pgl2I9bxp-gI4QPl1eB8b5Dij1nnIrzNuxJl0HHOAvH6gIHhoavo63_Q2zinUMsTGFNMe4oQ_UutpdPCBhPrvWpnKi47QjHsa-WVWvyHqmPU3qoYtLE1fyR4cyDYaOnKJkc3FxtDPgbf3oMqxZyTNg-fgaDY9ZSoPSX2PVXpV4f_98D-aSLyG9Akxls</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Luan, Wenkang</creator><creator>Qian, Yao</creator><creator>Ni, Xin</creator><creator>Bu, Xuefeng</creator><creator>Xia, Yun</creator><creator>Wang, Jinlong</creator><creator>Ruan, Hongru</creator><creator>Ma, Shaojun</creator><creator>Xu, Bin</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma</title><author>Luan, Wenkang ; Qian, Yao ; Ni, Xin ; Bu, Xuefeng ; Xia, Yun ; Wang, Jinlong ; Ruan, Hongru ; Ma, Shaojun ; Xu, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-d49fb2f110c7717f8fcae65e315e38a62d2764edcf2239d3cecdafb7092f7c743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>5-Fluorouracil</topic><topic>Analysis</topic><topic>Apoptosis</topic><topic>Care and treatment</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>Development and progression</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Lymphoma</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>Original Research</topic><topic>Physiological aspects</topic><topic>Plasmids</topic><topic>Prognosis</topic><topic>Prostate cancer</topic><topic>Skin cancer</topic><topic>Surgery</topic><topic>Tumor suppressor genes</topic><topic>Tumorigenesis</topic><topic>Xenografts</topic><topic>Zinc finger proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luan, Wenkang</creatorcontrib><creatorcontrib>Qian, Yao</creatorcontrib><creatorcontrib>Ni, Xin</creatorcontrib><creatorcontrib>Bu, Xuefeng</creatorcontrib><creatorcontrib>Xia, Yun</creatorcontrib><creatorcontrib>Wang, Jinlong</creatorcontrib><creatorcontrib>Ruan, Hongru</creatorcontrib><creatorcontrib>Ma, Shaojun</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>OncoTargets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luan, Wenkang</au><au>Qian, Yao</au><au>Ni, Xin</au><au>Bu, Xuefeng</au><au>Xia, Yun</au><au>Wang, Jinlong</au><au>Ruan, Hongru</au><au>Ma, Shaojun</au><au>Xu, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma</atitle><jtitle>OncoTargets and therapy</jtitle><addtitle>Onco Targets Ther</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>10</volume><spage>1237</spage><epage>1246</epage><pages>1237-1246</pages><issn>1178-6930</issn><eissn>1178-6930</eissn><abstract>An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in melanoma, especially in metastatic melanoma. miR-204-5p also served as a protective factor for the prognosis of melanoma patients. We determined that miR-204-5p suppresses cell proliferation, migration and invasion, and promotes cell apoptosis in melanoma. Matrix metalloproteinases-9 and B-cell lymphoma-2 are the functional targets of miR-204-5p, through which it plays an important biological role in malignant melanoma. The effect of miR-204-5p on malignant melanoma is verified using a xenograft model. We also determined that miR-204-5p increases 5-fluorouracil and cisplatin (DDP) chemosensitivity in malignant melanoma cells. This finding elucidates new functions and mechanisms for miR-204-5p in melanoma development, and provides potential therapeutic targets for the treatment of melanoma.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>28280358</pmid><doi>10.2147/OTT.S128819</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | 5-Fluorouracil Analysis Apoptosis Care and treatment Cell adhesion & migration Cell cycle Cell growth Development and progression Gene expression Health aspects Lymphoma Medical prognosis Melanoma Metastasis MicroRNA MicroRNAs Original Research Physiological aspects Plasmids Prognosis Prostate cancer Skin cancer Surgery Tumor suppressor genes Tumorigenesis Xenografts Zinc finger proteins |
| title | miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma |
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