Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population
Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong ass...
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| Veröffentlicht in: | Anatolian journal of cardiology 2015-03, Vol.15 (3), p.196-203 |
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| creator | Çakmak, Hüseyin Altuğ Bayoğlu, Burcu Durmaz, Eser Can, Günay Karadağ, Bilgehan Cengiz, Müjgan Vural, Vural Ali Yüksel, Hüsniye |
| description | Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong association with CAD in different populations. The aim of the present study was to investigate the association of two SNPs on chromosome 9p21 on susceptibility to CAD and the effect of these SNPs along with cardiovascular risk factors on the severity of CAD in the Turkish population.
This study had an observational case-control design. We genotyped 460 subjects, aged 30-65 years, to investigate the association of 2 SNPs (rs1333049, rs2383207) on chromosome 9p21 and CAD risk in Turkish population. Real-time polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in CAD patients and healthy controls. The genotype and allelic variations of these SNPs with the severity of CAD was also assessed using semi-quantitative methods such as the Gensini score. Student's t test and multiple regression analysis were used for statistical analysis.
The SNPs rs1333049 and rs2383207 were found to be associated with CAD with an adjusted OR of 1.81 (95% Cl 1.05-3.12) and 2.12 (95% CI 1.19-4.10) respectively. After adjustment of CAD risk factors such as smoking, family history of CAD and diabetes, the homozygous AA genotype for rs2383207 increased the CAD risk with an OR 3.69. Also a very strong association was found between rs1333049 and rs2383207 and Gensini scores representing the severity of CAD (p |
| doi_str_mv | 10.5152/akd.2014.5285 |
| format | Article |
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This study had an observational case-control design. We genotyped 460 subjects, aged 30-65 years, to investigate the association of 2 SNPs (rs1333049, rs2383207) on chromosome 9p21 and CAD risk in Turkish population. Real-time polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in CAD patients and healthy controls. The genotype and allelic variations of these SNPs with the severity of CAD was also assessed using semi-quantitative methods such as the Gensini score. Student's t test and multiple regression analysis were used for statistical analysis.
The SNPs rs1333049 and rs2383207 were found to be associated with CAD with an adjusted OR of 1.81 (95% Cl 1.05-3.12) and 2.12 (95% CI 1.19-4.10) respectively. After adjustment of CAD risk factors such as smoking, family history of CAD and diabetes, the homozygous AA genotype for rs2383207 increased the CAD risk with an OR 3.69. Also a very strong association was found between rs1333049 and rs2383207 and Gensini scores representing the severity of CAD (p<0.001).
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.</description><identifier>ISSN: 2149-2263</identifier><identifier>EISSN: 2149-2271</identifier><identifier>DOI: 10.5152/akd.2014.5285</identifier><identifier>PMID: 25333979</identifier><language>eng</language><publisher>Turkey: Kare Publishing</publisher><subject>Adult ; Aged ; Case-Control Studies ; Chromosomes, Human, Pair 9 - genetics ; Coronary Artery Disease - genetics ; Coronary Artery Disease - pathology ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Original Investigation ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Severity of Illness Index ; Turkey</subject><ispartof>Anatolian journal of cardiology, 2015-03, Vol.15 (3), p.196-203</ispartof><rights>Copyright Aves Yayincilik Ltd. STI. Mar 2015</rights><rights>Copyright © 2015 Turkish Society of Cardiology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-5c20ac7499384862d3da0b1bb465792ab32dc8e33e257382b47e4fce758c80e93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337054/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337054/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25333979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Çakmak, Hüseyin Altuğ</creatorcontrib><creatorcontrib>Bayoğlu, Burcu</creatorcontrib><creatorcontrib>Durmaz, Eser</creatorcontrib><creatorcontrib>Can, Günay</creatorcontrib><creatorcontrib>Karadağ, Bilgehan</creatorcontrib><creatorcontrib>Cengiz, Müjgan</creatorcontrib><creatorcontrib>Vural, Vural Ali</creatorcontrib><creatorcontrib>Yüksel, Hüsniye</creatorcontrib><title>Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population</title><title>Anatolian journal of cardiology</title><addtitle>Anatol J Cardiol</addtitle><description>Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong association with CAD in different populations. The aim of the present study was to investigate the association of two SNPs on chromosome 9p21 on susceptibility to CAD and the effect of these SNPs along with cardiovascular risk factors on the severity of CAD in the Turkish population.
This study had an observational case-control design. We genotyped 460 subjects, aged 30-65 years, to investigate the association of 2 SNPs (rs1333049, rs2383207) on chromosome 9p21 and CAD risk in Turkish population. Real-time polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in CAD patients and healthy controls. The genotype and allelic variations of these SNPs with the severity of CAD was also assessed using semi-quantitative methods such as the Gensini score. Student's t test and multiple regression analysis were used for statistical analysis.
The SNPs rs1333049 and rs2383207 were found to be associated with CAD with an adjusted OR of 1.81 (95% Cl 1.05-3.12) and 2.12 (95% CI 1.19-4.10) respectively. After adjustment of CAD risk factors such as smoking, family history of CAD and diabetes, the homozygous AA genotype for rs2383207 increased the CAD risk with an OR 3.69. Also a very strong association was found between rs1333049 and rs2383207 and Gensini scores representing the severity of CAD (p<0.001).
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - pathology</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Investigation</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Severity of Illness Index</subject><subject>Turkey</subject><issn>2149-2263</issn><issn>2149-2271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1v1DAQxS0EolXpkSuyxIVLFntsx84FCVXlQ6rEpZwtx5ntuk3sYCeLuPC342XLCjiNx_7pzTw_Ql5ytlFcwVv3MGyAcblRYNQTcg5cdg2A5k9P51ackctS7hljXAvDefucnIESQnS6Oyc_r_duXN0SUqRpS10pyYdj2-PyHTFSn6aptncYcQme7l0OLi6F1ju_y2lKJU1Iuxk4dXGoeE7R5R_U5QVrGUJBV5CGSG_X_BDKjs5pXsffQ16QZ1s3Frx8rBfk64fr26tPzc2Xj5-v3t80Xhq1NMoDc17LrhNGmhYGMTjW876XrdIduF7A4A0KgaCqSeilRrn1qJXxhmEnLsi7o-689hMOHuOS3WjnHKa6qk0u2H9fYtjZu7S39aM0U7IKvHkUyOnbimWxUygex9FFTGuxvNUSuAZgFX39H3qf1hyrvUq1qibAzYFqjpTPqZSM29MynNlDuLaGaw_h2kO4lX_1t4MT_SdK8QsyMqIg</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Çakmak, Hüseyin Altuğ</creator><creator>Bayoğlu, Burcu</creator><creator>Durmaz, Eser</creator><creator>Can, Günay</creator><creator>Karadağ, Bilgehan</creator><creator>Cengiz, Müjgan</creator><creator>Vural, Vural Ali</creator><creator>Yüksel, Hüsniye</creator><general>Kare Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population</title><author>Çakmak, Hüseyin Altuğ ; Bayoğlu, Burcu ; Durmaz, Eser ; Can, Günay ; Karadağ, Bilgehan ; Cengiz, Müjgan ; Vural, Vural Ali ; Yüksel, Hüsniye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-5c20ac7499384862d3da0b1bb465792ab32dc8e33e257382b47e4fce758c80e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - pathology</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Investigation</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Severity of Illness Index</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Çakmak, Hüseyin Altuğ</creatorcontrib><creatorcontrib>Bayoğlu, Burcu</creatorcontrib><creatorcontrib>Durmaz, Eser</creatorcontrib><creatorcontrib>Can, Günay</creatorcontrib><creatorcontrib>Karadağ, Bilgehan</creatorcontrib><creatorcontrib>Cengiz, Müjgan</creatorcontrib><creatorcontrib>Vural, Vural Ali</creatorcontrib><creatorcontrib>Yüksel, Hüsniye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Turkey Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Anatolian journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Çakmak, Hüseyin Altuğ</au><au>Bayoğlu, Burcu</au><au>Durmaz, Eser</au><au>Can, Günay</au><au>Karadağ, Bilgehan</au><au>Cengiz, Müjgan</au><au>Vural, Vural Ali</au><au>Yüksel, Hüsniye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population</atitle><jtitle>Anatolian journal of cardiology</jtitle><addtitle>Anatol J Cardiol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>15</volume><issue>3</issue><spage>196</spage><epage>203</epage><pages>196-203</pages><issn>2149-2263</issn><eissn>2149-2271</eissn><abstract>Coronary artery disease (CAD), which develops from complex interactions between genetic and enviromental factors, is a leading cause of death worldwide. Based on genome-wide association studies (GWAS), the chromosomal region 9p21 has been identified as the most relevant locus presenting a strong association with CAD in different populations. The aim of the present study was to investigate the association of two SNPs on chromosome 9p21 on susceptibility to CAD and the effect of these SNPs along with cardiovascular risk factors on the severity of CAD in the Turkish population.
This study had an observational case-control design. We genotyped 460 subjects, aged 30-65 years, to investigate the association of 2 SNPs (rs1333049, rs2383207) on chromosome 9p21 and CAD risk in Turkish population. Real-time polymerase chain reaction (RT-PCR) was used to analyze the 2 SNPs in CAD patients and healthy controls. The genotype and allelic variations of these SNPs with the severity of CAD was also assessed using semi-quantitative methods such as the Gensini score. Student's t test and multiple regression analysis were used for statistical analysis.
The SNPs rs1333049 and rs2383207 were found to be associated with CAD with an adjusted OR of 1.81 (95% Cl 1.05-3.12) and 2.12 (95% CI 1.19-4.10) respectively. After adjustment of CAD risk factors such as smoking, family history of CAD and diabetes, the homozygous AA genotype for rs2383207 increased the CAD risk with an OR 3.69. Also a very strong association was found between rs1333049 and rs2383207 and Gensini scores representing the severity of CAD (p<0.001).
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.</abstract><cop>Turkey</cop><pub>Kare Publishing</pub><pmid>25333979</pmid><doi>10.5152/akd.2014.5285</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Case-Control Studies Chromosomes, Human, Pair 9 - genetics Coronary Artery Disease - genetics Coronary Artery Disease - pathology European Continental Ancestry Group - genetics Female Genetic Predisposition to Disease Humans Male Middle Aged Original Investigation Polymerase Chain Reaction Polymorphism, Single Nucleotide Severity of Illness Index Turkey |
| title | Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population |
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