Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study
Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly. We included 56...
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| Veröffentlicht in: | Environmental health 2017-03, Vol.16 (1), p.17, Article 17 |
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| description | Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly.
We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.
The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81 μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P |
| doi_str_mv | 10.1186/s12940-017-0228-2 |
| format | Article |
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We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.
The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81 μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P < 0.05). The odds ratios of having abnormal ALT levels were statistically significant in the highest mercury quartile compared to those with the lowest quartile. Particularly, regular alcohol drinkers showed greater effect estimates of mercury on the liver function than non-drinkers groups. There was no mediation effect of oxidative stress in the relationship between blood mercury concentrations and liver function.
Our results suggest that blood mercury levels are associated with elevated liver enzymes and interact with alcohol consumption for the association in the elderly.</description><identifier>ISSN: 1476-069X</identifier><identifier>EISSN: 1476-069X</identifier><identifier>DOI: 10.1186/s12940-017-0228-2</identifier><identifier>PMID: 28257627</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alanine Transaminase - blood ; Alcohol Drinking - blood ; Alcohol Drinking - urine ; Alcohols ; Analysis ; Aspartate ; Aspartate Aminotransferases - blood ; Blood ; Blood lipids ; Cardiovascular disease ; Cross-sectional studies ; Environmental health ; Environmental Pollutants - blood ; Enzymes ; Female ; gamma-Glutamyltransferase - blood ; Health aspects ; Heavy metals ; Humans ; Life Style ; Liver ; Liver Diseases - blood ; Liver Diseases - urine ; Male ; Malondialdehyde - urine ; Mercury ; Mercury - blood ; Mercury compounds ; Middle Aged ; Nutrition ; Obesity ; Obesity - blood ; Older people ; Oxidative stress ; Population ; Republic of Korea</subject><ispartof>Environmental health, 2017-03, Vol.16 (1), p.17, Article 17</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-a54a824e09dcd51d922eef30491689451389797034004fc0393c78f25b5c53963</citedby><cites>FETCH-LOGICAL-c494t-a54a824e09dcd51d922eef30491689451389797034004fc0393c78f25b5c53963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336614/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336614/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28257627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Mee-Ri</creatorcontrib><creatorcontrib>Lim, Youn-Hee</creatorcontrib><creatorcontrib>Lee, Bo-Eun</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><title>Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study</title><title>Environmental health</title><addtitle>Environ Health</addtitle><description>Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly.
We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.
The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81 μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P < 0.05). The odds ratios of having abnormal ALT levels were statistically significant in the highest mercury quartile compared to those with the lowest quartile. Particularly, regular alcohol drinkers showed greater effect estimates of mercury on the liver function than non-drinkers groups. There was no mediation effect of oxidative stress in the relationship between blood mercury concentrations and liver function.
Our results suggest that blood mercury levels are associated with elevated liver enzymes and interact with alcohol consumption for the association in the elderly.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alanine Transaminase - blood</subject><subject>Alcohol Drinking - blood</subject><subject>Alcohol Drinking - urine</subject><subject>Alcohols</subject><subject>Analysis</subject><subject>Aspartate</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Blood</subject><subject>Blood lipids</subject><subject>Cardiovascular disease</subject><subject>Cross-sectional studies</subject><subject>Environmental health</subject><subject>Environmental Pollutants - blood</subject><subject>Enzymes</subject><subject>Female</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Health aspects</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Life Style</subject><subject>Liver</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - urine</subject><subject>Male</subject><subject>Malondialdehyde - urine</subject><subject>Mercury</subject><subject>Mercury - blood</subject><subject>Mercury compounds</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Older people</subject><subject>Oxidative stress</subject><subject>Population</subject><subject>Republic of Korea</subject><issn>1476-069X</issn><issn>1476-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkU1rFjEUhQdRbK3-ADcScD0135O4EGqxKhTcKLgLaXKnTckkYzJTef-9mb61tiBZJNw853DvPV33muBjQpR8VwnVHPeYDD2mVPX0SXdI-CB7LPXPpw_eB92LWq9xA5UUz7sDqqgYJB0Ou_Ix5uzRBMWtZYdcTg7SUuwScqrIFkC21uyCXcCj32G5Qh5cDAlQSCiGGyhoXJPb8K1iE4LoocQdmvO8xluf98ii2SaIqC6r373sno02Vnh1dx91P84-fT_90p9_-_z19OS8d1zzpbeCW0U5YO2dF8RrSgFGhrkmUmkuCFN60ANmHGM-Osw0c4MaqbgQTjAt2VH3Ye87rxcT-P1c0cwlTLbsTLbBPP5J4cpc5hsjGJOS8Gbw9s6g5F8r1MVc57Wk1rMhauCYCaXwP-rSRjAhjbmZuSlUZ064YlpwSjfq-D9UOx6m0LYOY2j1RwKyF7iSay0w3jdOsNnSN_v0TQvVbOkb2jRvHk58r_gbN_sDVrKqxA</recordid><startdate>20170304</startdate><enddate>20170304</enddate><creator>Lee, Mee-Ri</creator><creator>Lim, Youn-Hee</creator><creator>Lee, Bo-Eun</creator><creator>Hong, Yun-Chul</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>5PM</scope></search><sort><creationdate>20170304</creationdate><title>Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study</title><author>Lee, Mee-Ri ; Lim, Youn-Hee ; Lee, Bo-Eun ; Hong, Yun-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-a54a824e09dcd51d922eef30491689451389797034004fc0393c78f25b5c53963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alanine Transaminase - blood</topic><topic>Alcohol Drinking - blood</topic><topic>Alcohol Drinking - urine</topic><topic>Alcohols</topic><topic>Analysis</topic><topic>Aspartate</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Blood</topic><topic>Blood lipids</topic><topic>Cardiovascular disease</topic><topic>Cross-sectional studies</topic><topic>Environmental health</topic><topic>Environmental Pollutants - blood</topic><topic>Enzymes</topic><topic>Female</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Health aspects</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Life Style</topic><topic>Liver</topic><topic>Liver Diseases - blood</topic><topic>Liver Diseases - urine</topic><topic>Male</topic><topic>Malondialdehyde - urine</topic><topic>Mercury</topic><topic>Mercury - blood</topic><topic>Mercury compounds</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Older people</topic><topic>Oxidative stress</topic><topic>Population</topic><topic>Republic of Korea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Mee-Ri</creatorcontrib><creatorcontrib>Lim, Youn-Hee</creatorcontrib><creatorcontrib>Lee, Bo-Eun</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Mee-Ri</au><au>Lim, Youn-Hee</au><au>Lee, Bo-Eun</au><au>Hong, Yun-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study</atitle><jtitle>Environmental health</jtitle><addtitle>Environ Health</addtitle><date>2017-03-04</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>17</spage><pages>17-</pages><artnum>17</artnum><issn>1476-069X</issn><eissn>1476-069X</eissn><abstract>Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly.
We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.
The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81 μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P < 0.05). The odds ratios of having abnormal ALT levels were statistically significant in the highest mercury quartile compared to those with the lowest quartile. Particularly, regular alcohol drinkers showed greater effect estimates of mercury on the liver function than non-drinkers groups. There was no mediation effect of oxidative stress in the relationship between blood mercury concentrations and liver function.
Our results suggest that blood mercury levels are associated with elevated liver enzymes and interact with alcohol consumption for the association in the elderly.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28257627</pmid><doi>10.1186/s12940-017-0228-2</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alanine Transaminase - blood Alcohol Drinking - blood Alcohol Drinking - urine Alcohols Analysis Aspartate Aspartate Aminotransferases - blood Blood Blood lipids Cardiovascular disease Cross-sectional studies Environmental health Environmental Pollutants - blood Enzymes Female gamma-Glutamyltransferase - blood Health aspects Heavy metals Humans Life Style Liver Liver Diseases - blood Liver Diseases - urine Male Malondialdehyde - urine Mercury Mercury - blood Mercury compounds Middle Aged Nutrition Obesity Obesity - blood Older people Oxidative stress Population Republic of Korea |
| title | Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study |
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