A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

Bone metastases remain a serious health concern because of limited therapeutic options. Here, we report that crosstalk between ROR1–HER3 and the Hippo–YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion. Mechanistically, the orphan receptor tyrosine kinase RO...

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Veröffentlicht in:	Nature cell biology 2017-02, Vol.19 (2), p.106-119
Hauptverfasser:	Li, Chunlai, Wang, Shouyu, Xing, Zhen, Lin, Aifu, Liang, Ke, Song, Jian, Hu, Qingsong, Yao, Jun, Chen, Zhongyuan, Park, Peter K., Hawke, David H., Zhou, Jianwei, Zhou, Yan, Zhang, Shuxing, Liang, Han, Hung, Mien-Chie, Gallick, Gary E., Han, Leng, Lin, Chunru, Yang, Liuqing
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/2568 631/67 631/67/322 631/80/641/83/2360 Adaptor Proteins, Signal Transducing - metabolism Biology Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone tumors Breast cancer Cancer metastasis Cancer Research Cell Biology Cell growth Cell Line, Tumor Cell Proliferation - physiology Cell receptors Cellular signal transduction Complications and side effects Developmental Biology Genes Genetic aspects Health aspects Humans Inactivation Kinases Life Sciences Metastasis Oncology Ovarian cancer Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proteins Public health Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Receptor, ErbB-3 - metabolism Risk factors RNA, Long Noncoding - metabolism Signal Transduction Stem Cells Toxicology Transcription Factors
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