Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding

c-Myc-interacting zinc finger protein-1 (Miz-1) is a poly-Cys2His2 zinc finger (ZF) transcriptional regulator of many cell cycle genes. A Miz-1 DNA sequence consensus has recently been identified and has also unveiled Miz-1 functions in other cellular processes, underscoring its importance in the ce...

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Veröffentlicht in:	The Journal of biological chemistry 2017-02, Vol.292 (8), p.3323-3340
Hauptverfasser:	Bédard, Mikaël, Roy, Vincent, Montagne, Martin, Lavigne, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence DNA - metabolism Humans Kruppel-Like Transcription Factors - chemistry Kruppel-Like Transcription Factors - metabolism Models, Molecular Protein Conformation Protein Folding Protein Structure and Folding Sequence Alignment Zinc Fingers
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