Dynamics of Methylated Cytosine Flipping by UHRF1

DNA methylation patterns, which are critical for gene expression, are replicated by DNA methyltransferase 1 (DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins. This replication is initiated by the recognition of hemimethylated CpG sites and further flipping of methy...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-02, Vol.139 (6), p.2520-2528
Hauptverfasser:	Kilin, Vasyl, Gavvala, Krishna, Barthes, Nicolas P. F, Michel, Benoît Y, Shin, Dongwon, Boudier, Christian, Mauffret, Olivier, Yashchuk, Valeriy, Mousli, Marc, Ruff, Marc, Granger, Florence, Eiler, Sylvia, Bronner, Christian, Tor, Yitzhak, Burger, Alain, Mély, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	CCAAT-Enhancer-Binding Proteins - chemistry CCAAT-Enhancer-Binding Proteins - metabolism Cytosine - chemistry Cytosine - metabolism DNA - chemistry DNA - metabolism DNA Methylation DNA Replication Fluorescence Humans Kinetics Life Sciences Molecular Structure Thermodynamics Ubiquitin-Protein Ligases
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