Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer

PD-L1 is expressed in a percentage of lung cancer patients and those patients show increased likelihood of response to PD-1 axis therapies. However, the methods and assays for the assessment of PD-L1 using immunohistochemistry are variable and PD-L1 expression appears to be highly heterogeneous. Her...

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Veröffentlicht in:Modern pathology 2017-03, Vol.30 (3), p.340-349
Hauptverfasser: Rehman, Jamaal A, Han, Gang, Carvajal-Hausdorf, Daniel E, Wasserman, Brad E, Pelekanou, Vasiliki, Mani, Nikita L, McLaughlin, Joseph, Schalper, Kurt A, Rimm, David L
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Sprache:eng
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