Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis
Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, pred...
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| Veröffentlicht in: | Genes 2017-01, Vol.8 (2), p.50-50 |
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| creator | Fris, Megan E Broach, William H Klim, Sarah E Coschigano, Peter W Carroll, Ronan K Caswell, Clayton C Murphy, Erin R |
| description | Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In S. dysenteriae, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of ompC, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species. |
| doi_str_mv | 10.3390/genes8020050 |
| format | Article |
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Here, we characterize RyfA1, one member of a sibling pair of sRNAs produced by S. dysenteriae. Unlike its nearly identical sibling molecule, RyfA2, predicted to be encoded almost exclusively by non-pathogenic species, the presence of a gene encoding RyfA1, or a RyfA1-like molecule, is strongly correlated with virulence in a variety of enteropathogens. In S. dysenteriae, the overproduction of RyfA1 negatively impacts the virulence-associated process of cell-to-cell spread as well as the expression of ompC, a gene encoding a major outer membrane protein important for the pathogenesis of Shigella. Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes8020050</identifier><identifier>PMID: 28134784</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Gene regulation ; Major outer membrane protein ; Membrane proteins ; Pathogenesis ; Ribonucleic acid ; RNA ; Shigella ; Shigella dysenteriae ; Virulence</subject><ispartof>Genes, 2017-01, Vol.8 (2), p.50-50</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-44f670ed2da4503be026a77b458d9c1c11c3cc5f1c3d44303fd4dbbfe2e92e423</citedby><cites>FETCH-LOGICAL-c445t-44f670ed2da4503be026a77b458d9c1c11c3cc5f1c3d44303fd4dbbfe2e92e423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333039/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333039/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28134784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fris, Megan E</creatorcontrib><creatorcontrib>Broach, William H</creatorcontrib><creatorcontrib>Klim, Sarah E</creatorcontrib><creatorcontrib>Coschigano, Peter W</creatorcontrib><creatorcontrib>Carroll, Ronan K</creatorcontrib><creatorcontrib>Caswell, Clayton C</creatorcontrib><creatorcontrib>Murphy, Erin R</creatorcontrib><title>Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. 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Interestingly, the production of RyfA1 is controlled by a second sRNA, here termed RyfB1, the first incidence of one regulatory small RNA controlling another in S. dysenteriae or any Shigella species.</description><subject>Gene regulation</subject><subject>Major outer membrane protein</subject><subject>Membrane proteins</subject><subject>Pathogenesis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Shigella</subject><subject>Shigella dysenteriae</subject><subject>Virulence</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctKw0AUhgdRrNTuXIvgxoXVuSWTbIRSb4Wi0up6mExO2ilpUjOJ0LfJs-TJnF4s1ZWzOQPn4z__OT9CZwTfMBbi2wlkYANMMfbwATqhWLAu59Q73Pu3UMfaGXaPr8Fj1KIBYVwE_ATdj02UmmzS1Hb00mvq0TLpkaYeZElaQabBNvV4aiaQpqqp46WFrITCKLh4U-U0X4839hQdJSq10NnWNvp4fHjvP3eHr0-Dfm_Y1Zx7pTOT-AJDTGPFPcwiwNRXQkTcC-JQE02IZlp7iSsx5wyzJOZxFCVAIaTAKWuju43uoormEGtnplCpXBRmroqlzJWRvzuZmcpJ_iU9xpxc6ASutgJF_lmBLeXcWL1aLoO8spIEAREe8yn-B-rTkAmfCode_kFneVVk7hKOcld2koI76npD6SK3toBk55tguQpT7ofp8PP9XXfwT3TsGxAenp8</recordid><startdate>20170126</startdate><enddate>20170126</enddate><creator>Fris, Megan E</creator><creator>Broach, William H</creator><creator>Klim, Sarah E</creator><creator>Coschigano, Peter W</creator><creator>Carroll, Ronan K</creator><creator>Caswell, Clayton C</creator><creator>Murphy, Erin R</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20170126</creationdate><title>Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis</title><author>Fris, Megan E ; Broach, William H ; Klim, Sarah E ; Coschigano, Peter W ; Carroll, Ronan K ; Caswell, Clayton C ; Murphy, Erin R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-44f670ed2da4503be026a77b458d9c1c11c3cc5f1c3d44303fd4dbbfe2e92e423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Gene regulation</topic><topic>Major outer membrane protein</topic><topic>Membrane proteins</topic><topic>Pathogenesis</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Shigella</topic><topic>Shigella dysenteriae</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fris, Megan E</creatorcontrib><creatorcontrib>Broach, William H</creatorcontrib><creatorcontrib>Klim, Sarah E</creatorcontrib><creatorcontrib>Coschigano, Peter W</creatorcontrib><creatorcontrib>Carroll, Ronan K</creatorcontrib><creatorcontrib>Caswell, Clayton C</creatorcontrib><creatorcontrib>Murphy, Erin R</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fris, Megan E</au><au>Broach, William H</au><au>Klim, Sarah E</au><au>Coschigano, Peter W</au><au>Carroll, Ronan K</au><au>Caswell, Clayton C</au><au>Murphy, Erin R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2017-01-26</date><risdate>2017</risdate><volume>8</volume><issue>2</issue><spage>50</spage><epage>50</epage><pages>50-50</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>Small regulatory RNAs (sRNAs) of Shigella dysenteriae and other pathogens are vital for the regulation of virulence-associated genes and processes. 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| subjects | Gene regulation Major outer membrane protein Membrane proteins Pathogenesis Ribonucleic acid RNA Shigella Shigella dysenteriae Virulence |
| title | Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis |
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