TRIM8 regulates stemness in glioblastoma through PIAS3‐STAT3

Glioblastoma (GBM) is the most malignant form of primary brain tumor, and GBM stem‐like cells (GSCs) contribute to the rapid growth, therapeutic resistance, and clinical recurrence of these fatal tumors. STAT3 signaling supports the maintenance and proliferation of GSCs, yet regulatory mechanisms ar...

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Veröffentlicht in:	Molecular oncology 2017-03, Vol.11 (3), p.280-294
Hauptverfasser:	Zhang, Changming, Mukherjee, Subhas, Tucker‐Burden, Carol, Ross, James L., Chau, Monica J., Kong, Jun, Brat, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - metabolism Brain - pathology Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Genes glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Health aspects Humans Molecular Chaperones - genetics Molecular Chaperones - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism PIAS3 Protein Inhibitors of Activated STAT - genetics Protein Inhibitors of Activated STAT - metabolism RNA Interference RNA, Small Interfering - genetics Signal Transduction STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism stem cell Stem cells TRIM8
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