Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infreque...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2017-03, Vol.127 (3), p.830-842
Hauptverfasser:	Kent, Lindsey N, Bae, Sooin, Tsai, Shih-Yin, Tang, Xing, Srivastava, Arunima, Koivisto, Christopher, Martin, Chelsea K, Ridolfi, Elisa, Miller, Grace C, Zorko, Sarah M, Plevris, Emilia, Hadjiyannis, Yannis, Perez, Miguel, Nolan, Eric, Kladney, Raleigh, Westendorp, Bart, de Bruin, Alain, Fernandez, Soledad, Rosol, Thomas J, Pohar, Kamal S, Pipas, James M, Leone, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical research Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell cycle Cell growth Colleges & universities DNA binding proteins E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism E2F3 Transcription Factor - genetics E2F3 Transcription Factor - metabolism Epigenetics Gene Dosage Gene expression Gene mutation Genes, Neoplasm Genetic aspects Genomics Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Mice Mice, Knockout Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Risk factors Rodents Software Transcription factors Tumors Values
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!