p53 switches off pluripotency on differentiation

The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like c...

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Veröffentlicht in:	Stem cell research & therapy 2017-02, Vol.8 (1), p.44-44, Article 44
Hauptverfasser:	Lin, Tongxiang, Lin, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell- and Tissue-Based Therapy Embryonic Stem Cells Gene Expression Regulation, Neoplastic Humans Mice Molecular Targeted Therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Neoplastic Stem Cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Review Signal Transduction Stem Cell Transplantation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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