Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression

The A2B receptor (A2BR) can mediate adenosine-induced tumor proliferation, immunosuppression and angiogenesis. Targeting the A2BR has proved to be therapeutically effective in some murine tumor models, but the mechanisms of these effects are still incompletely understood. Here, we report that pharma...

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Veröffentlicht in:	Oncotarget 2016-09, Vol.7 (39), p.64274-64288
Hauptverfasser:	Sorrentino, Claudia, Miele, Lucio, Porta, Amalia, Pinto, Aldo, Morello, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Agonists - pharmacology Adenosine A2 Receptor Antagonists - pharmacology Animals Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Cell Line, Tumor Cell Proliferation - drug effects Chemokine CXCL12 - metabolism Disease Progression Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblast Growth Factor 2 - metabolism Gelatinases - metabolism Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Membrane Proteins - metabolism Mice Mice, Inbred C57BL Paracrine Communication Phosphorylation Receptor, Adenosine A2B - drug effects Receptor, Adenosine A2B - metabolism Research Paper Serine Endopeptidases - metabolism Signal Transduction Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Stromal Cells - drug effects Stromal Cells - metabolism Stromal Cells - pathology Time Factors Tumor Hypoxia Tumor Microenvironment
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