CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo

We analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice). We demonstrate that silencing of CEACAM1 in WAP-T tumor-derived G-2 cells...

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Veröffentlicht in:	Oncotarget 2016-09, Vol.7 (39), p.63730-63746
Hauptverfasser:	Wegwitz, Florian, Lenfert, Eva, Gerstel, Daniela, von Ehrenstein, Lena, Einhoff, Julia, Schmidt, Geske, Logsdon, Matthew, Brandner, Johanna, Tiegs, Gisa, Beauchemin, Nicole, Wagener, Christoph, Deppert, Wolfgang, Horst, Andrea Kristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism beta Catenin - metabolism Biomarkers, Tumor - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoembryonic Antigen - metabolism Carcinoma - metabolism Cell Adhesion Molecules - metabolism Cell Line, Tumor Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans In Vitro Techniques Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Neoplasm Invasiveness Neoplasm Metastasis Phenotype Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Research Paper Signal Transduction Up-Regulation
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