Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet

We have developed an unnatural base pair (UBP) and a semisynthetic organism (SSO) that imports the constituent unnatural nucleoside triphosphates and uses them to replicate DNA containing the UBP. However, propagation of the UBP is at least in part limited by the stability of the unnatural triphosph...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-02, Vol.139 (6), p.2464-2467
Hauptverfasser:	Feldman, Aaron W, Dien, Vivian T, Romesberg, Floyd E
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing DNA DNA - chemistry DNA - genetics DNA Replication Genetic Code Hydrocarbons, Fluorinated - chemistry nucleosides Nucleotides - chemistry oxygen Oxygen - chemistry Polyphosphates - chemistry
Online-Zugang:	Volltext
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