Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD
Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty‐four adults with moderate to...
Gespeichert in:
| Veröffentlicht in: | Indoor air 2016-10, Vol.26 (5), p.734-742 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 742 |
|---|---|
| container_issue | 5 |
| container_start_page | 734 |
| container_title | Indoor air |
| container_volume | 26 |
| creator | Bose, S. Rivera-Mariani, F. Chen, R. Williams, D. Belli, A. Aloe, C. McCormack, M. C. Breysse, P. N. Hansel, N. N. |
| description | Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty‐four adults with moderate to severe COPD were followed longitudinally and indoor air and dust samples collected at baseline, 3 and 6 months. Respiratory outcomes were repeatedly assessed at each time point. The associations between endotoxin exposure in air and settled dust and health outcomes were explored using generalizing estimating equations in multivariate models accounting for confounders. Dust endotoxin concentrations in the main living area were highest in spring and lowest in fall, while airborne endotoxins remained steady across seasons. Airborne and dust endotoxin concentrations were weakly correlated with one another (rs = +0.24, P = 0.005). Endotoxin concentrations were not significantly associated with respiratory symptoms, rescue medication use, quality of life, or severe exacerbations. In vitro whole‐blood assays of the pro‐inflammatory capacity of PM10 filters with and without endotoxin depletion demonstrated that the endotoxin component of indoor air pollution was not the primary trigger for interleukin‐1β release. Our findings support that endotoxin is not the major driver in the adverse effects of indoor PM upon COPD morbidity. |
| doi_str_mv | 10.1111/ina.12264 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5324735</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1823029562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6524-c0415d2aac8129bdc0d998041701b27037cbf62e657ad9022cc163edd881fb343</originalsourceid><addsrcrecordid>eNqNkl9PFDEUxRujkQV98AuYJr7ow0D_t_NiQhZBIgGja3xsOm1HCjPTtZ2B3W9vcWGjJkb7cpPe3z1pzz0AvMBoH5dzEAazjwkR7BGYYYFQhYRQj8EM1YhXomZyB-zmfIUQlrSmT8EOEZxJpuoZWBzF3ucxWOhXy5in5OEYoR9cHOMqDNAMDiaflyGZMaY17GNqggvjGpZmG1PvE8x9vPYpw9swXsL5xcejZ-BJa7rsn9_XPfDl-N1i_r46uzg5nR-eVVZwwiqLGOaOGGMVJnXjLHJ1rcqlRLghElFpm1YQL7g0rkaEWIsF9c4phduGMroH3m50l1PTe2f9MCbT6WUKvUlrHU3Qv3eGcKm_xRvNKWGS8iLw-l4gxe9T8UH3IVvfdWbwccoaK8YVYbS85d8okUohKej_oBSRmgtS0Fd_oFdxSkMx7Y4ilGCsZKHebCibYs7Jt9svYqTvEqBLAvTPBBT25a-ebMmHlRfgYAPchs6v_66kT88PHySrzUTIo19tJ0y61kJSyfXX8xP9mZIF-XCM9Cf6A8SDyNw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1822321187</pqid></control><display><type>article</type><title>Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bose, S. ; Rivera-Mariani, F. ; Chen, R. ; Williams, D. ; Belli, A. ; Aloe, C. ; McCormack, M. C. ; Breysse, P. N. ; Hansel, N. N.</creator><creatorcontrib>Bose, S. ; Rivera-Mariani, F. ; Chen, R. ; Williams, D. ; Belli, A. ; Aloe, C. ; McCormack, M. C. ; Breysse, P. N. ; Hansel, N. N.</creatorcontrib><description>Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty‐four adults with moderate to severe COPD were followed longitudinally and indoor air and dust samples collected at baseline, 3 and 6 months. Respiratory outcomes were repeatedly assessed at each time point. The associations between endotoxin exposure in air and settled dust and health outcomes were explored using generalizing estimating equations in multivariate models accounting for confounders. Dust endotoxin concentrations in the main living area were highest in spring and lowest in fall, while airborne endotoxins remained steady across seasons. Airborne and dust endotoxin concentrations were weakly correlated with one another (rs = +0.24, P = 0.005). Endotoxin concentrations were not significantly associated with respiratory symptoms, rescue medication use, quality of life, or severe exacerbations. In vitro whole‐blood assays of the pro‐inflammatory capacity of PM10 filters with and without endotoxin depletion demonstrated that the endotoxin component of indoor air pollution was not the primary trigger for interleukin‐1β release. Our findings support that endotoxin is not the major driver in the adverse effects of indoor PM upon COPD morbidity.</description><identifier>ISSN: 0905-6947</identifier><identifier>EISSN: 1600-0668</identifier><identifier>DOI: 10.1111/ina.12264</identifier><identifier>PMID: 26547489</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adults ; Aged ; Air Pollution, Indoor - adverse effects ; Air Pollution, Indoor - analysis ; Chronic obstructive pulmonary disease ; Dust ; Dust - analysis ; Endotoxin ; Endotoxins ; Endotoxins - analysis ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Estimating ; Exposure ; Female ; Health ; Housing ; Humans ; Indoor air ; Indoor air pollution ; Indoor air quality ; Interleukin-1β ; Longitudinal Studies ; Male ; Middle Aged ; Morbidity ; Particulate matter ; Pollution ; Pulmonary Disease, Chronic Obstructive - etiology ; Respiratory diseases ; Seasons ; Smoking ; Smoking - adverse effects ; Time Factors ; Toxins</subject><ispartof>Indoor air, 2016-10, Vol.26 (5), p.734-742</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6524-c0415d2aac8129bdc0d998041701b27037cbf62e657ad9022cc163edd881fb343</citedby><cites>FETCH-LOGICAL-c6524-c0415d2aac8129bdc0d998041701b27037cbf62e657ad9022cc163edd881fb343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fina.12264$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fina.12264$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26547489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bose, S.</creatorcontrib><creatorcontrib>Rivera-Mariani, F.</creatorcontrib><creatorcontrib>Chen, R.</creatorcontrib><creatorcontrib>Williams, D.</creatorcontrib><creatorcontrib>Belli, A.</creatorcontrib><creatorcontrib>Aloe, C.</creatorcontrib><creatorcontrib>McCormack, M. C.</creatorcontrib><creatorcontrib>Breysse, P. N.</creatorcontrib><creatorcontrib>Hansel, N. N.</creatorcontrib><title>Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD</title><title>Indoor air</title><addtitle>Indoor Air</addtitle><description>Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty‐four adults with moderate to severe COPD were followed longitudinally and indoor air and dust samples collected at baseline, 3 and 6 months. Respiratory outcomes were repeatedly assessed at each time point. The associations between endotoxin exposure in air and settled dust and health outcomes were explored using generalizing estimating equations in multivariate models accounting for confounders. Dust endotoxin concentrations in the main living area were highest in spring and lowest in fall, while airborne endotoxins remained steady across seasons. Airborne and dust endotoxin concentrations were weakly correlated with one another (rs = +0.24, P = 0.005). Endotoxin concentrations were not significantly associated with respiratory symptoms, rescue medication use, quality of life, or severe exacerbations. In vitro whole‐blood assays of the pro‐inflammatory capacity of PM10 filters with and without endotoxin depletion demonstrated that the endotoxin component of indoor air pollution was not the primary trigger for interleukin‐1β release. Our findings support that endotoxin is not the major driver in the adverse effects of indoor PM upon COPD morbidity.</description><subject>Adults</subject><subject>Aged</subject><subject>Air Pollution, Indoor - adverse effects</subject><subject>Air Pollution, Indoor - analysis</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Dust</subject><subject>Dust - analysis</subject><subject>Endotoxin</subject><subject>Endotoxins</subject><subject>Endotoxins - analysis</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Estimating</subject><subject>Exposure</subject><subject>Female</subject><subject>Health</subject><subject>Housing</subject><subject>Humans</subject><subject>Indoor air</subject><subject>Indoor air pollution</subject><subject>Indoor air quality</subject><subject>Interleukin-1β</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Particulate matter</subject><subject>Pollution</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Respiratory diseases</subject><subject>Seasons</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Time Factors</subject><subject>Toxins</subject><issn>0905-6947</issn><issn>1600-0668</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl9PFDEUxRujkQV98AuYJr7ow0D_t_NiQhZBIgGja3xsOm1HCjPTtZ2B3W9vcWGjJkb7cpPe3z1pzz0AvMBoH5dzEAazjwkR7BGYYYFQhYRQj8EM1YhXomZyB-zmfIUQlrSmT8EOEZxJpuoZWBzF3ucxWOhXy5in5OEYoR9cHOMqDNAMDiaflyGZMaY17GNqggvjGpZmG1PvE8x9vPYpw9swXsL5xcejZ-BJa7rsn9_XPfDl-N1i_r46uzg5nR-eVVZwwiqLGOaOGGMVJnXjLHJ1rcqlRLghElFpm1YQL7g0rkaEWIsF9c4phduGMroH3m50l1PTe2f9MCbT6WUKvUlrHU3Qv3eGcKm_xRvNKWGS8iLw-l4gxe9T8UH3IVvfdWbwccoaK8YVYbS85d8okUohKej_oBSRmgtS0Fd_oFdxSkMx7Y4ilGCsZKHebCibYs7Jt9svYqTvEqBLAvTPBBT25a-ebMmHlRfgYAPchs6v_66kT88PHySrzUTIo19tJ0y61kJSyfXX8xP9mZIF-XCM9Cf6A8SDyNw</recordid><startdate>201610</startdate><enddate>201610</enddate><creator>Bose, S.</creator><creator>Rivera-Mariani, F.</creator><creator>Chen, R.</creator><creator>Williams, D.</creator><creator>Belli, A.</creator><creator>Aloe, C.</creator><creator>McCormack, M. C.</creator><creator>Breysse, P. N.</creator><creator>Hansel, N. N.</creator><general>Blackwell Publishing Ltd</general><general>Hindawi Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>SOI</scope><scope>7X8</scope><scope>7T7</scope><scope>7TV</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201610</creationdate><title>Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD</title><author>Bose, S. ; Rivera-Mariani, F. ; Chen, R. ; Williams, D. ; Belli, A. ; Aloe, C. ; McCormack, M. C. ; Breysse, P. N. ; Hansel, N. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6524-c0415d2aac8129bdc0d998041701b27037cbf62e657ad9022cc163edd881fb343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Air Pollution, Indoor - adverse effects</topic><topic>Air Pollution, Indoor - analysis</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Dust</topic><topic>Dust - analysis</topic><topic>Endotoxin</topic><topic>Endotoxins</topic><topic>Endotoxins - analysis</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - analysis</topic><topic>Estimating</topic><topic>Exposure</topic><topic>Female</topic><topic>Health</topic><topic>Housing</topic><topic>Humans</topic><topic>Indoor air</topic><topic>Indoor air pollution</topic><topic>Indoor air quality</topic><topic>Interleukin-1β</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Particulate matter</topic><topic>Pollution</topic><topic>Pulmonary Disease, Chronic Obstructive - etiology</topic><topic>Respiratory diseases</topic><topic>Seasons</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Time Factors</topic><topic>Toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bose, S.</creatorcontrib><creatorcontrib>Rivera-Mariani, F.</creatorcontrib><creatorcontrib>Chen, R.</creatorcontrib><creatorcontrib>Williams, D.</creatorcontrib><creatorcontrib>Belli, A.</creatorcontrib><creatorcontrib>Aloe, C.</creatorcontrib><creatorcontrib>McCormack, M. C.</creatorcontrib><creatorcontrib>Breysse, P. N.</creatorcontrib><creatorcontrib>Hansel, N. N.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indoor air</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bose, S.</au><au>Rivera-Mariani, F.</au><au>Chen, R.</au><au>Williams, D.</au><au>Belli, A.</au><au>Aloe, C.</au><au>McCormack, M. C.</au><au>Breysse, P. N.</au><au>Hansel, N. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD</atitle><jtitle>Indoor air</jtitle><addtitle>Indoor Air</addtitle><date>2016-10</date><risdate>2016</risdate><volume>26</volume><issue>5</issue><spage>734</spage><epage>742</epage><pages>734-742</pages><issn>0905-6947</issn><eissn>1600-0668</eissn><abstract>Indoor air pollution has been linked to adverse chronic obstructive pulmonary disease (COPD) health, but specific causative agents have not yet been identified. We evaluated the role of indoor endotoxin exposure upon respiratory health in former smokers with COPD. Eighty‐four adults with moderate to severe COPD were followed longitudinally and indoor air and dust samples collected at baseline, 3 and 6 months. Respiratory outcomes were repeatedly assessed at each time point. The associations between endotoxin exposure in air and settled dust and health outcomes were explored using generalizing estimating equations in multivariate models accounting for confounders. Dust endotoxin concentrations in the main living area were highest in spring and lowest in fall, while airborne endotoxins remained steady across seasons. Airborne and dust endotoxin concentrations were weakly correlated with one another (rs = +0.24, P = 0.005). Endotoxin concentrations were not significantly associated with respiratory symptoms, rescue medication use, quality of life, or severe exacerbations. In vitro whole‐blood assays of the pro‐inflammatory capacity of PM10 filters with and without endotoxin depletion demonstrated that the endotoxin component of indoor air pollution was not the primary trigger for interleukin‐1β release. Our findings support that endotoxin is not the major driver in the adverse effects of indoor PM upon COPD morbidity.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26547489</pmid><doi>10.1111/ina.12264</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-6947 |
| ispartof | Indoor air, 2016-10, Vol.26 (5), p.734-742 |
| issn | 0905-6947 1600-0668 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5324735 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adults Aged Air Pollution, Indoor - adverse effects Air Pollution, Indoor - analysis Chronic obstructive pulmonary disease Dust Dust - analysis Endotoxin Endotoxins Endotoxins - analysis Environmental Exposure - adverse effects Environmental Exposure - analysis Estimating Exposure Female Health Housing Humans Indoor air Indoor air pollution Indoor air quality Interleukin-1β Longitudinal Studies Male Middle Aged Morbidity Particulate matter Pollution Pulmonary Disease, Chronic Obstructive - etiology Respiratory diseases Seasons Smoking Smoking - adverse effects Time Factors Toxins |
| title | Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A25%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Domestic%20exposure%20to%20endotoxin%20and%20respiratory%20morbidity%20in%20former%20smokers%20with%20COPD&rft.jtitle=Indoor%20air&rft.au=Bose,%20S.&rft.date=2016-10&rft.volume=26&rft.issue=5&rft.spage=734&rft.epage=742&rft.pages=734-742&rft.issn=0905-6947&rft.eissn=1600-0668&rft_id=info:doi/10.1111/ina.12264&rft_dat=%3Cproquest_pubme%3E1823029562%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1822321187&rft_id=info:pmid/26547489&rfr_iscdi=true |