Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8)

Infiltrating immune cells including monocytes/macrophages have been implicated in the pathogenesis of neovascular age-related macular degeneration (nAMD). The aim of this study was to investigate the cytokine and chemokine expression and secretion profile of peripheral blood mononuclear cells (PBMCs...

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Veröffentlicht in:	Journal of neuroinflammation 2017-02, Vol.14 (1), p.42-42, Article 42
Hauptverfasser:	Lechner, Judith, Chen, Mei, Hogg, Ruth E, Toth, Levente, Silvestri, Giuliana, Chakravarthy, Usha, Xu, Heping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Angiogenesis Inhibitors - administration & dosage Cells, Cultured Chemokine CCL2 - biosynthesis Choroidal Neovascularization - drug therapy Choroidal Neovascularization - immunology Choroidal Neovascularization - metabolism Female Humans Interleukin-8 - biosynthesis Intravitreal Injections Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Macular Degeneration - drug therapy Macular Degeneration - immunology Macular Degeneration - metabolism Male Middle Aged Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism
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