Macrophages of genetically characterized familial hypercholesterolaemia patients show up‐regulation of LDL‐receptor‐related proteins

Familial hypercholesterolaemia (FH) is a major risk for premature coronary heart disease due to severe long‐life exposure to high LDL levels. Accumulation of LDL in the vascular wall triggers atherosclerosis with activation of the innate immunity system. Here, we have investigated (i) gene expressio...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2017-03, Vol.21 (3), p.487-499
Hauptverfasser:	Escate, Rafael, Padro, Teresa, Borrell‐Pages, Maria, Suades, Rosa, Aledo, Rosa, Mata, Pedro, Badimon, Lina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Animals Antigens, CD - genetics Antigens, Differentiation, Myelomonocytic - genetics Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Blood cells Cardiovascular disease Cardiovascular diseases CD163 CD163 antigen Cell differentiation Cholesterol Cholesterol, LDL - genetics Coronary artery disease Exposure familial hypercholesterolaemia Female Gene expression Genotype & phenotype Health risks Heart diseases Heterozygote Humans Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - metabolism Immunity, Innate - genetics Inflammation Innate immunity LDL-Receptor Related Proteins - genetics Lipids Low density lipoprotein Low Density Lipoprotein Receptor-Related Protein-1 - genetics Low Density Lipoprotein Receptor-Related Protein-5 - genetics LRP5 protein LRPs Macrophages Macrophages - metabolism Male Mice Mice, Inbred C57BL Middle Aged Monocytes Mutation Mutation - genetics Original Oxidative stress Patients Peripheral blood Proteins Receptors, Cell Surface - genetics Receptors, LDL - genetics Scavenger receptors Statistical analysis Studies Transcription Up-regulation Up-Regulation - genetics
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