Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation

To identify potential anti-cancer constituents in natural extracts that inhibit cancer cell growth and migration. Our experiments used high dose thymoquinone (TQ) as an inhibitor to arrest LoVo (a human colon adenocarcinoma cell line) cancer cell growth, which was detected by cell proliferation assa...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2017-02, Vol.23 (7), p.1171-1179
Hauptverfasser:	Hsu, Hsi-Hsien, Chen, Ming-Cheng, Day, Cecilia Hsuan, Lin, Yueh-Min, Li, Shin-Yi, Tu, Chuan-Chou, Padma, Viswanadha Vijaya, Shih, Hui-Nung, Kuo, Wei-Wen, Huang, Chih-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Antineoplastic Agents - therapeutic use Basic Study Benzoquinones - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Nucleus - metabolism Cell Proliferation Cell Survival Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Cyclooxygenase 2 - metabolism Dinoprostone - metabolism Humans Mice Mice, Nude Neoplasm Transplantation Phytochemicals - therapeutic use Signal Transduction
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