Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Hypothermic circulatory arrest (HCA) provides neuroprotection during cardiac surgery but entails an ischemic period that can lead to excitotoxicity, neuroinflammation, and subsequent neurologic injury. Hydroxyl polyamidoamine (PAMAM) dendrimers target activated microglia and damaged neurons in the i...

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Veröffentlicht in:	Journal of controlled release 2017-03, Vol.249, p.173-182
Hauptverfasser:	Zhang, Fan, Trent Magruder, J., Lin, Yi-An, Crawford, Todd C., Grimm, Joshua C., Sciortino, Christopher M., Wilson, Mary Ann, Blue, Mary E., Kannan, Sujatha, Johnston, Michael V., Baumgartner, William A., Kannan, Rangaramanujam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Biodistribution blood circulation blood serum brain Brain - metabolism Brain Injuries - drug therapy Brain Injuries - metabolism Brain penetration Canine model cerebrospinal fluid CSF/serum ratio Dendrimer Dendrimers - administration & dosage Dendrimers - chemistry Dendrimers - pharmacokinetics Disease Models, Animal Dogs Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Delivery Systems drugs Hypothermic circulatory arrest intravenous injection Kidney - metabolism liver Liver - metabolism Male neuroglia neurons neuroprotective effect pharmacokinetics renal clearance spleen surgery
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