Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention

It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, CSC-targeting strategies have not been efficiently translated to the clinic. This...

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Veröffentlicht in:	Molecular cancer 2017-02, Vol.16 (1), p.43-43, Article 43
Hauptverfasser:	Gasch, Claudia, Ffrench, Brendan, O'Leary, John J, Gallagher, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents Cancer treatment Cell Differentiation Drug Resistance, Neoplasm - drug effects Humans Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Physiological aspects Properties Review Signal Transduction - drug effects Stem cells
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