Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats
Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also h...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-7 |
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| creator | Abu Bakar, Sazaly Nor-Amdan, Nur-Asyura Lim, Tong-Hye Mat-Rahim, Nor Aziyah |
| description | Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver. |
| doi_str_mv | 10.1155/2017/6125829 |
| format | Article |
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These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2017/6125829</identifier><identifier>PMID: 28280515</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Chinese medicine ; Developing countries ; Enzymes ; Histochemistry ; Histology ; Injuries ; Laboratory animals ; LDCs ; Liver cirrhosis ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Medicine, Oriental ; Phosphatase ; Phosphatases ; Proteins ; Rodents</subject><ispartof>Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-7</ispartof><rights>Copyright © 2017 Nor Aziyah Mat-Rahim et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Nor Aziyah Mat-Rahim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Nor Aziyah Mat-Rahim et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-b7589c0af941a7262217c03d60831a03edb785bf4d018257a6e002cafb0d78f43</citedby><cites>FETCH-LOGICAL-c499t-b7589c0af941a7262217c03d60831a03edb785bf4d018257a6e002cafb0d78f43</cites><orcidid>0000-0003-2560-3871 ; 0000-0002-9267-1420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322457/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322457/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28280515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dini, Luciana</contributor><creatorcontrib>Abu Bakar, Sazaly</creatorcontrib><creatorcontrib>Nor-Amdan, Nur-Asyura</creatorcontrib><creatorcontrib>Lim, Tong-Hye</creatorcontrib><creatorcontrib>Mat-Rahim, Nor Aziyah</creatorcontrib><title>Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.</description><subject>Chinese medicine</subject><subject>Developing countries</subject><subject>Enzymes</subject><subject>Histochemistry</subject><subject>Histology</subject><subject>Injuries</subject><subject>Laboratory animals</subject><subject>LDCs</subject><subject>Liver cirrhosis</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Medicine, Oriental</subject><subject>Phosphatase</subject><subject>Phosphatases</subject><subject>Proteins</subject><subject>Rodents</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkcFrFDEYxUNR2lp78ywBL4Jdmy-TTDIXoaytK6wIorS3kMl86abMTrbJbMX_3iy7bqsnIZAH-eV9eXmEvAL2HkDKc85AndfApebNATkGJWAiuNbP9lrdHJEXOd8xxhul1CE54pprJkEek-sZruwYVymO6MbwgPTS-6IyjZ5OF2HAjPQLdsEVSWeY2kw_oouFjQMta17uJDoNKS1iDpmGgX6zY35JnnvbZzzd7Sfkx9Xl9-lsMv_66fP0Yj5xomnGSaukbhyzvhFgFa85B-VY1dVMV2BZhV2rtGy96BhoLpWtsaRw1resU9qL6oR82Pqu1u0SO4fDmGxvViksbfplog3m75MhLMxtfDCy4lxIVQze7gxSvF9jHs0yZId9bweM62xAq1o0unxwQd_8g97FdRpKvA3FuGigekLd2h5NGHwsc93G1FxIWbNaiEoX6mxLuRRzTuj3TwZmNr2aTa9m12vBXz-NuYf_FFmAd1ugVNbZn-E_7bAw6O0jDVJw0NVvkPqy0A</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Abu Bakar, Sazaly</creator><creator>Nor-Amdan, Nur-Asyura</creator><creator>Lim, Tong-Hye</creator><creator>Mat-Rahim, Nor Aziyah</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2560-3871</orcidid><orcidid>https://orcid.org/0000-0002-9267-1420</orcidid></search><sort><creationdate>20170101</creationdate><title>Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats</title><author>Abu Bakar, Sazaly ; 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These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28280515</pmid><doi>10.1155/2017/6125829</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2560-3871</orcidid><orcidid>https://orcid.org/0000-0002-9267-1420</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Chinese medicine Developing countries Enzymes Histochemistry Histology Injuries Laboratory animals LDCs Liver cirrhosis Medicinal plants Medicine, Botanic Medicine, Herbal Medicine, Oriental Phosphatase Phosphatases Proteins Rodents |
| title | Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats |
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