LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism

Liver kinase B1 (LKB1) is mutationally inactivated in Peutz–Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated...

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Veröffentlicht in:	Oncogene 2017-03, Vol.36 (9), p.1245-1255
Hauptverfasser:	Zeng, Q, Chen, J, Li, Y, Werle, K D, Zhao, R-X, Quan, C-S, Wang, Y-S, Zhai, Y-X, Wang, J-W, Youssef, M, Cui, R, Liang, J, Genovese, N, Chow, L T, Li, Y-L, Xu, Z-X
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/51 13/95 631/67/1858 631/80/304 96/109 Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism c-Myc protein Care and treatment Case-Control Studies Cell Biology Cell growth Cell metabolism Cell migration Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cervical cancer Cervix Complications and side effects Development and progression Ectopic expression Embryo fibroblasts Female Follow-Up Studies Genetic aspects Glucose - metabolism Glycolysis Glycolysis - physiology Health aspects Hepatocytes Hexokinase Hexokinase - genetics Hexokinase - metabolism Human Genetics Human papillomavirus Human papillomavirus 16 - physiology Humans Internal Medicine Kinases Lactic acid Liver cancer LKB1 protein Medicine Medicine & Public Health Metabolism Metastases Mice Mice, Inbred C57BL Mutation Myc protein Neoplasm Staging Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - metabolism Oncology original-article Papillomaviridae Papillomavirus E7 Proteins - genetics Papillomavirus E7 Proteins - metabolism Papillomavirus infections Papillomavirus Infections - metabolism Papillomavirus Infections - pathology Papillomavirus Infections - virology Phosphotransferases Prognosis Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Senescence Transformed cells Tumor Cells, Cultured Tumorigenesis Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology
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