Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated protein (Yap) as a critical regulator of the immunosuppressive microenvironment in both mouse and human PDAC. Within Kras:p53 mutant pancreatic d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2017-03, Vol.36 (9), p.1232-1244
Hauptverfasser:	Murakami, S, Shahbazian, D, Surana, R, Zhang, W, Chen, H, Graham, G T, White, S M, Weiner, L M, Yi, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/327 64/60 82 82/51 96/21 96/31 96/95 Acute Disease Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Adenocarcinoma Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Analysis Animals Apoptosis Biomarkers, Tumor - metabolism Cancer Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Care and treatment Cell Biology Cell Cycle Proteins Cell Differentiation Cell Proliferation Chemokines Cytokines Cytokines - metabolism Diagnosis Health aspects Human Genetics Humans Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Internal Medicine Lymphocytes T Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Medicine Medicine & Public Health Mice Microenvironments Mutants Mutation - genetics Myeloid-Derived Suppressor Cells - immunology Myeloid-Derived Suppressor Cells - metabolism Myeloid-Derived Suppressor Cells - pathology Neoplasm Staging Oncology original-article p53 Protein Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatitis Pancreatitis - immunology Pancreatitis - metabolism Pancreatitis - pathology Phosphoproteins - genetics Phosphoproteins - metabolism Phosphoproteins - physiology Prognosis Proteins Proto-Oncogene Proteins p21(ras) - genetics Risk factors Suppressor cells Survival Rate T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Therapeutic targets Transcription Factors Tumor Cells, Cultured Tumor proteins Xenograft Model Antitumor Assays YAP-Signaling Proteins Yes-associated protein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!