Secretory phospholipase A2 in the pathogenesis of acute dengue infection

Introduction Platelet activating factor (PAF) is an important mediator of vascular leak in acute dengue. Phospholipase A2s (PLA2) are inflammatory lipid enzymes that generate and regulate PAF and other mediators associated with mast cells. We sought to investigate if mast cell activation and increas...

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Veröffentlicht in:	Immunity, Inflammation and Disease Inflammation and Disease, 2017-03, Vol.5 (1), p.7-15
Hauptverfasser:	Jeewandara, Chandima, Gomes, Laksiri, Udari, Sukhitha, Paranavitane, S.A., Shyamali, N.L.A., Ogg, Graham S., Malavige, Gathsaurie Neelika
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Antibodies, Viral - blood Autophagy Cytokines Dengue - blood Dengue - metabolism Dengue - virology Dengue fever Dengue Virus - genetics Enzymes Humans Illnesses Immunoglobulins Infections Lipids mast cell tryptase Mast Cells - metabolism Original Research Pathogenesis Permeability Phospholipases A2, Secretory - blood platelet activating factor Platelet Activating Factor - metabolism RNA, Viral - analysis secretory phospholipase severe dengue Tryptases - metabolism Vascular endothelial growth factor vascular leak Viral Nonstructural Proteins - metabolism
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