A supramolecular assembly mediates lentiviral DNA integration

Retroviral integrase (IN) functions within the intasome nucleoprotein complex to catalyze insertion of viral DNA into cellular chromatin. Using cryo–electron microscopy, we now visualize the functional maedi-visna lentivirus intasome at 4.9 angstrom resolution. The intasome comprises a homo-hexadeca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-01, Vol.355 (6320), p.93-95
Hauptverfasser:	Ballandras-Colas, Allison, Maskell, Daniel P., Serrao, Erik, Locke, Julia, Swuec, Paolo, Jónsson, Stefán R., Kotecha, Abhay, Cook, Nicola J., Pye, Valerie E., Taylor, Ian A., Andrésdóttir, Valgerdur, Engelman, Alan N., Costa, Alessandro, Cherepanov, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Biochemistry Catalytic Domain Chromatin Cryoelectron Microscopy Deoxyribonucleic acid Design engineering DNA DNA structure DNA, Viral - chemistry DNA, Viral - ultrastructure Drug Design Electron microscopy Genomes HIV HIV Integrase - chemistry HIV Integrase - ultrastructure HIV Integrase Inhibitors - chemistry HIV-1 - chemistry HIV-1 - enzymology HIV-1 - ultrastructure Human immunodeficiency virus Humans Infections Insertion Integrase Integration Lentivirus Life cycle engineering Life cycles Life Sciences Maedi Maedi-visna virus Models, Molecular Platforms Protein Domains Retroviridae Static Electricity Transmission electron microscopy Virus Assembly Virus Integration Viruses Visna
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!